ArticleJournal of medical Internet research2020
Data Validation and Verification Using Blockchain in a Clinical Trial for Breast Cancer: Regulatory Sandbox.
Article in Journal of medical Internet research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Applications of Blockchain in the Medical Field: Narrative Review.Journal of medical Internet research · 2021Pooled it
- Cardiorespiratory fitness in breast cancer survivors: a randomised controlled trial of home-based smartphone supported high intensity interval training.BMJ supportive & palliative care · 2022Trial
- Blockchain for Digital Health Governance: Evidence Gap Map and Scoping Review.Journal of medical Internet research · 2026Article
- Blockchain Technology to Enhance Clinical Data Management in Healthcare: A Systematic Literature Review.Blockchain in healthcare today · 2026Review
- Enhancing randomized clinical trials with digital twins.NPJ systems biology and applications · 2025Review
- Enhancing Cancer Care through Blockchain Technology.Asian Pacific journal of cancer prevention : APJCP · 2025Review
- Artificial intelligence and blockchain in clinical trials: enhancing data governance efficiency, integrity, and transparency.Bioanalysis · 2025Review
- A data management system for precision medicine.PLOS digital health · 2025Article
- Effective Integration of Artificial Intelligence and Blockchain Technologies for Empowerment of Drug Discovery and Development.Current drug discovery technologies · 2025Review
- Blockchain-enabled quality by design system for clinical trials.Frontiers in medicine · 2025Article
- Blockchain as a Prime Guardian: Securing Clinical Trial Data Integrity.Reviews on recent clinical trials · 2025Review
- Blockchain Applications in Core Healthcare Services: Patient Data, Research, and Institutional Processes.Blockchain in healthcare today · 2025Article
- Resilience of hospitals in an age of disruptions: a systematic literature review on resources and capabilities.Health systems (Basingstoke, England) · 2024Review
- Awareness and intention-to-use of digital health applications, artificial intelligence and blockchain technology in breast cancer care.Frontiers in medicine · 2024Article
- Blockchain integration in healthcare: a comprehensive investigation of use cases, performance issues, and mitigation strategies.Frontiers in digital health · 2024Review
- Blockchain and COVID-19 pandemic: applications and challenges.Cluster computing · 2023Review
- Use Case Evaluation and Digital Workflow of Breast Cancer Care by Artificial Intelligence and Blockchain Technology Application.Healthcare (Basel, Switzerland) · 2022Article
- Comorbid insomnia among breast cancer survivors and its prediction using machine learning: a nationwide study in Japan.Japanese journal of clinical oncology · 2022Article
- Is blockchain ready for orthopaedics? A systematic review.Journal of clinical orthopaedics and trauma · 2021Review
- Potential of blockchain approach on development and security of microbial databases.Biological procedures online · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe integrity of data in a clinical trial is essential, but the current data management process is too complex and highly labor-intensive. As a result, clinical trials are prone to consuming a lot of budget and time, and there is a risk for human-induced error and data falsification. Blockchain technology has the potential to address some of these challenges.
objectiveThe aim of the study was to validate a system that enables the security of medical data in a clinical trial using blockchain technology.
methodsWe have developed a blockchain-based data management system for clinical trials and tested the system through a clinical trial for breast cancer. The project was conducted to demonstrate clinical data management using blockchain technology under the regulatory sandbox enabled by the Japanese Cabinet Office.
resultsWe verified and validated the data in the clinical trial using the validation protocol and tested its resilience to data tampering. The robustness of the system was also proven by survival with zero downtime for clinical data registration during a Amazon Web Services disruption event in the Tokyo region on August 23, 2019.
conclusionsWe show that our system can improve clinical trial data management, enhance trust in the clinical research process, and ease regulator burden. The system will contribute to the sustainability of health care services through the optimization of cost for clinical trials.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.