Evidence map›Paper›PMID 32340797›Full record

ArticleUltrasound in medicine & biology2020

3-D-Printed Registration Phantom for Combined Ultrasound and Optical Imaging of Biological Tissues.

Michael A Pinkert, Benjamin L Cox, Bing Dai, Timothy J Hall, Kevin W Eliceiri

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultrasound in medicine & biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Michael A PinkertMorgridge Institute for Research, Madison, Wisconsin, USA; Laboratory for Optical and Computational Instrumentation, University of Wisconsin-Madison, Madison, Wisconsin, USA; Department of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Benjamin L CoxLaboratory for Optical and Computational Instrumentation, University of Wisconsin-Madison, Madison, Wisconsin, USA; Department of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Bing DaiLaboratory for Optical and Computational Instrumentation, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Timothy J HallDepartment of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Kevin W EliceiriMorgridge Institute for Research, Madison, Wisconsin, USA; Laboratory for Optical and Computational Instrumentation, University of Wisconsin-Madison, Madison, Wisconsin, USA; Department of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, USA; Department of Biomedical Engineering, University of Wisconsin Madison, Madison, Wisconsin, USA. Electronic address: eliceiri@wisc.edu.
University of Wisconsin–Madison · USMorgridge Institute for Research · US

Funding

BIOTECHNOLOGY TRAINING PROGRAMT32GM008349 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI FOX, BRIAN G · 1989 to 2019
$22.5M
U.W. RADIOLOGICAL SCIENCES TRAINING PROGRAMT32CA009206 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Bryan Patrick Bednarz · 1985 to 2026
$12.1M
Monitoring Changes in Cervical Microstructure During PregnancyR01HD072077 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI FELTOVICH, HELEN, HALL, TIMOTHY J · 2013 to 2022
$6.1M
NCI NIH HHS T32 CA009206NICHD NIH HHS R01 HD072077NIGMS NIH HHS T32 GM008349
6 · The paper itself

Abstract

Efforts to develop quantitative ultrasound biomarkers would benefit from comparisons between ultrasound data and higher-resolution images of the tissue microstructure, such as from optical microscopy. However, only a few studies have used these methods for multiscale imaging because it is difficult to register low-resolution (>100 μm) ultrasound images to high-resolution microscopy images. To address this need, we have designed a 3-D-printed registration phantom that is made of a hard fluorescent resin, fits into a glass-bottom dish and can be used to calculate a coordinate system transform between ultrasound and optical microscopy. We report the phantom design, a registration protocol and an example registration using 18.5-MHz ultrasound and second harmonic generation microscopy. We evaluate the registration precision, achieving standard deviations smaller than the ultrasound resolution across all axes, and illustrate on a mouse mammary gland that this method yields results superior to those of manual landmark registration.

Indexed as

Phantoms, ImagingPrinting, Three-DimensionalAnimalsFemaleHumansMammary Glands, AnimalMiceMicroscopy, ConfocalOptical ImagingUltrasonography3-D printingImage registrationMultiscale imagingOptical microscopyPhantomUltrasound

Identifiers

PMID32340797
PMCPMC7293928
OpenAlexW3019942695

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.