Evidence map›Paper›PMID 32340506›Full record

ArticleJournal of the American Heart Association2020

Greater Daily Psychosocial Stress Exposure is Associated With Increased Norepinephrine-Induced Vasoconstriction in Young Adults.

Jody L Greaney, Agus Surachman, Erika F H Saunders, Lacy M Alexander, David M Almeida

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05619601 (Gender Differences in Prevention Strategies and Therapeutic Adherence After Acute Myocardial Infarction - GENAMI PREVENTION), which is not on this map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05619601 completednot on this mapstarted 2023, after this paper: background citation

Gender Differences in Prevention Strategies and Therapeutic Adherence After Acute Myocardial Infarction - GENAMI PREVENTION

Typeobservational_patient_registrySponsorSpanish Society of CardiologyRan2023 to 2026Enrolled530ConditionsGender Differences, Adherence, Medication, Therapeutic Adherence, Type 1 Acute Myocardial Infarction
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 45 citations in OpenAlex.

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  14. Blood pressure and muscle sympathetic nerve activity are associated with trait anxiety in humans.American journal of physiology. Heart and circulatory physiology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jody L GreaneyNoll Laboratory Department of Kinesiology The Pennsylvania State University University Park PA.
Agus SurachmanDepartment of Human Development and Family Studies The Pennsylvania State University University Park PA.
Erika F H SaundersDepartment of Psychiatry Penn State College of Medicine Hershey PA.
Lacy M AlexanderNoll Laboratory Department of Kinesiology The Pennsylvania State University University Park PA.
David M AlmeidaDepartment of Human Development and Family Studies The Pennsylvania State University University Park PA.
Pennsylvania State University · USPenn State Milton S. Hershey Medical Center · US

Funding

Penn State Clinical and Translational Science InstituteUL1TR002014 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KRASCHNEWSKI, JENNIFER L. · 2016 to 2025
$33.7M
Psychosocial Determinants and Biological Pathway to Healthy Aging (Pathways)T32AG049676 · NIA · PENNSYLVANIA STATE UNIVERSITY, THE · PI LYNN M. MARTIRE · 2016 to 2026
$3.9M
Peripheral and Central Mechanisms of Neurovascular Dysfunction in Human DepressionR00HL133414 · NHLBI · UNIVERSITY OF TEXAS ARLINGTON · PI GREANEY, JODY · 2019 to 2021
$746k
Peripheral and Central Mechanisms of Neurovascular Dysfunction in Human DepressionK99HL133414 · NHLBI · PENNSYLVANIA STATE UNIVERSITY, THE · PI GREANEY, JODY · 2017 to 2018
$209k
NCATS NIH HHS UL1 TR002014NHLBI NIH HHS K99 HL133414NHLBI NIH HHS R00 HL133414NIA NIH HHS T32 AG049676
6 · The paper itself

Abstract

Background Epidemiological data suggest a link between psychological stress and increased cardiovascular disease risk; however, the underlying mechanisms remain incompletely understood. The purpose of this investigation was to directly examine the influence of daily psychosocial stress on microvascular adrenergic vasoconstrictor responsiveness in healthy adults. We hypothesized increased daily psychosocial stress would be positively related to increased norepinephrine-induced vasoconstriction. Methods and Results Eighteen healthy adults (19-36 years; 10 women) completed a daily psychosocial experiences telephone interview for 8 consecutive evenings in order to document their exposure and emotional responsiveness to common stressors (eg, arguments, work stress) over the preceding 24 hrs. On the last interview day, red cell flux (laser Doppler flowmetry) was measured during graded intradermal microdialysis perfusion of norepinephrine (10

Indexed as

Administration, CutaneousAdultAge FactorsDose-Response Relationship, DrugEmotionsFemaleHumansMaleMicrocirculationMicrodialysisMiddle AgedNorepinephrineStress, PsychologicalTime FactorsVasoconstrictionVasoconstrictor AgentsNorepinephrineVasoconstrictor Agentsdaily stressmicrodialysismicrovascular functionskin blood flowsympathetic reactivity

Identifiers

PMID32340506
PMCPMC7428556
OpenAlexW3020084175

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.