ArticleCirculation. Genomic and precision medicine2020
Genetically Determined Birthweight Associates With Atrial Fibrillation: A Mendelian Randomization Study.
Article in Circulation. Genomic and precision medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- DNA methylation informs adult cardiovascular risk and prevention for low birthweight individuals.Journal of global health · 2026Article
- Birth weight, cardiovascular health, and the risk of cardiovascular disease: A longitudinal perspective from the UK biobank cohort.American journal of preventive cardiology · 2025Article
- Birth weight influences cardiac structure, function, and disease risk: evidence of a causal association.European heart journal · 2024Article
- Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes.Genome biology · 2024Article
- Assessing causal association of circulating micronutrients and systemic lupus erythematosus susceptibility: a Mendelian randomization study.Frontiers in nutrition · 2024Article
- Opposite causal effects of birthweight on myocardial infarction and atrial fibrillation and the distinct mediating pathways: a Mendelian randomization study.Cardiovascular diabetology · 2023Article
- The Penn Medicine BioBank: Towards a Genomics-Enabled Learning Healthcare System to Accelerate Precision Medicine in a Diverse Population.Journal of personalized medicine · 2022Article
- Both indirect maternal and direct fetal genetic effects reflect the observational relationship between higher birth weight and lower adult bone mass.BMC medicine · 2022Article
- A phenome-wide bidirectional Mendelian randomization analysis of atrial fibrillation.International journal of epidemiology · 2022Article
- Epigenetic Modifications at the Center of the Barker Hypothesis and Their Transgenerational Implications.International journal of environmental research and public health · 2021Review
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14 authors at 4 institutions in 1 country.
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Abstract
backgroundAtrial fibrillation is a common cardiovascular disorder, characterized by irregular electrical activity in the upper chambers of the heart. Both chronic cardiometabolic risk factors and genetics have been shown to contribute to the development of atrial fibrillation. Birthweight has also been associated with risk of atrial fibrillation.
methodsIn the current study, we utilized a genetic approach to study the effect of birthweight on atrial fibrillation. We used 2-sample Mendelian randomization to consider the impact of birthweight on incident atrial fibrillation using summary data from the Early Growth Genetics Consortium GWAS of birthweight and a large biobank-based GWAS of atrial fibrillation.
resultsUsing the framework of 2-sample Mendelian randomization, we found that a 1-SD genetic elevation of birthweight was associated with increased risk of atrial fibrillation (odds ratio, 1.27 [95% CI, 1.14-1.41];
conclusionsOur findings clarify the directionality of the relationship between birthweight and atrial fibrillation, supporting the growing body of evidence that intrauterine growth has a lifelong impact on cardiovascular health.
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