ArticleLangmuir : the ACS journal of surfaces and colloids2020
Physicochemical Characterization of Daptomycin Interaction with Negatively Charged Lipid Membranes.
Article in Langmuir : the ACS journal of surfaces and colloids, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Differential Impact of Ergosterol on Yeast Membranes Exposed to Membrane-Targeting Antimicrobial Compounds.Chembiochem : a European journal of chemical biology · 2026Article
- State of the Art of Cyclic Lipopeptide-Membrane Interactions: Pore Formation and Bilayer Permeability.Pharmaceutics · 2025Review
- Mechanistic Insights into Lipooligourea-Lipid Membrane Interactions.The journal of physical chemistry. B · 2025Article
- The effects of 3-hydroxyflavone complexes with transition metal ions on the physicochemical and microbial properties of bacterial cell membranes.Scientific reports · 2025Article
- DefectivemSphere · 2024Article
- Defective pgsA contributes to increased membrane fluidity and cell wall thickening in S. aureus with high-level daptomycin resistance.bioRxiv : the preprint server for biology · 2024Article
- Gram-Positive Bacterial Membrane-Based Biosensor for Multimodal Investigation of Membrane-Antibiotic Interactions.Biosensors · 2024Article
- Article
- Harnessing the Role of Bacterial Plasma Membrane Modifications for the Development of Sustainable Membranotropic Phytotherapeutics.Membranes · 2022Review
- Solid and Liquid Surface-Supported Bacterial Membrane Mimetics as a Platform for the Functional and Structural Studies of Antimicrobials.Membranes · 2022Review
- Impact of PrsA on membrane lipid composition during daptomycin-resistance-mediated β-lactam sensitization in clinical MRSA strains.The Journal of antimicrobial chemotherapy · 2021Article
- Binding Studies Reveal Phospholipid Specificity and Its Role in the Calcium-Dependent Mechanism of Action of Daptomycin.ACS infectious diseases · 2021Article
- Designing a Useful Lipid Raft Model Membrane for Electrochemical and Surface Analytical Studies.Molecules (Basel, Switzerland) · 2021Article
- The Antibiotic Peptide Daptomycin Functions by Reorganizing the Membrane.The Journal of membrane biology · 2021Review
- Physicochemical and Biological Characterization of Novel Membrane-Active Cationic Lipopeptides with Antimicrobial Properties.Langmuir : the ACS journal of surfaces and colloids · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Daptomycin is known as an effective antibiotic lipopeptide which shows activity against the number of Gram-positive pathogens. Its primary target is the bacterial cell membrane. However, the detailed mechanism of daptomycin action is still subject to debate. In this paper, we have investigated the interactions between lipopeptide and model lipid films composed of negatively charged phosphatidylglycerols and cardiolipin. In order to evaluate the effect of daptomycin on the molecular organization and the properties of lipid assemblies, we have used surface pressure measurements and electrochemical methods combined with atomic force microscopy, quartz crystal microbalance, and surface-enhanced infrared absorption spectroscopy. Our results indicate that daptomycin interaction with the lipid membrane is complex. It involves daptomycin aggregation and partial insertion, which in turn affect the charge distribution on both sides of the membrane and may result in a gradient of water chemical potential. The latter can drive the flux of water across the membrane.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.