Evidence map›Paper›PMID 32340436›Full record

ArticleGut and liver2021

A Prospective Multicenter Study of Partially Covered Metal Stents in Patients Receiving Neoadjuvant Chemotherapy for Resectable and Borderline Resectable Pancreatic Cancer: BTS-NAC Study.

Kei Saito, Yousuke Nakai, Hiroyuki Isayama, Ryuichi Yamamoto, Kazumichi Kawakubo, Yuzo Kodama, Akio Katanuma, Atsushi Kanno, Masahiro Itonaga, Kazuhiko Koike

Abstract readMulticenter Study
In one paragraph

Article in Gut and liver, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kei SaitoDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Japan.ORCID 0000-0003-2290-9373
Yousuke NakaiDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Japan.ORCID 0000-0001-7411-1385
Hiroyuki IsayamaDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Japan.ORCID 0000-0002-3308-9326
Ryuichi YamamotoDepartment of Gastroenterology and Hepatology, Saitama Medical Center, Saitama Medical University, Saitama, Japan.ORCID 0000-0003-0299-5470
Kazumichi KawakuboDepartment of Gastroenterology and Hepatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.ORCID 0000-0002-8979-9474
Yuzo KodamaDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID 0000-0002-1741-5638
Akio KatanumaDepartment of Gastroenterology, Teine-Keijinkai Hospital, Sapporo, Japan.ORCID 0000-0003-3548-5215
Atsushi KannoDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.ORCID 0000-0001-6341-5199
Masahiro ItonagaSecond Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan.ORCID 0000-0002-0343-7246
Kazuhiko KoikeDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Japan.ORCID 0000-0002-9787-1907

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/Aims: The aim of this study was to evaluate the safety and efficacy of partially covered self-expandable metallic stents (PCSEMS) in patients undergoing neoadjuvant chemo(radio) therapy (NAC) for pancreatic cancer (PC). Methods: This was a prospective multicenter study to evaluate the safety and efficacy of PCSEMS in patients receiving NAC for resectable and borderline resectable PC. The primary endpoint was the rate of recurrent biliary obstruction (RBO). Results: Twenty-six patients with PC (three with resectable PC and 23 with borderline resectable PC) who underwent NAC at seven Japanese centers were included in the analysis. Both the technical and functional success rates of PCSEMS placement were 100%. Early stent-related complications were observed in three patients (11.5%): mild pancreatitis (n=2) and mild liver abscess (n=1). The median time to surgery or palliation was 4.0 months. Surgical resection was eventually performed in 73.1% of patients, and stent removal during surgery was successful in all patients. RBO was observed in nine patients (34.6%): seven with stent occlusion, one with kinking and one with migration. The RBO rates in resected cases and nonresected cases were 36.8% and 28.6%, respectively. Conclusions: Biliary drainage by PCSEMS was safe and feasible in patients undergoing NAC for resectable and borderline resectable PC.

Indexed as

CholestasisPancreatic NeoplasmsSelf Expandable Metallic StentsHumansNeoadjuvant TherapyProspective StudiesStentsTreatment OutcomeBiliary obstructionNeoadjuvant therapyPancreatic neoplasmsSelf expandable metallic stents

Identifiers

PMID32340436
PMCPMC7817930

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.