Trial reportNutrients2020
Effect of Increased Daily Water Intake and Hydration on Health in Japanese Adults.
Trial report in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Outcomes in Randomized Clinical Trials Testing Changes in Daily Water Intake: A Systematic Review.JAMA network open · 2024Pooled it
- Metabolic impact of a nutrition education program for the promotion of fruit and vegetable consumption with people with severe mental disorders (DIETMENT).BMC research notes · 2022Trial
- Trial
- Associations of fluid intake patterns, hydration status, and metabolic dysfunction-associated steatotic liver disease (MASLD): a cross-sectional study in older adults.Scientific reports · 2026Article
- Nicotinamide mononucleotide attenuates hepatic endoplasmic reticulum stress and modulates circadian rhythms in young mice with diet-induced obesity.Nutrition research and practice · 2026Article
- Occupational Physical Activity and Blood Pressure: The Role of Leisure Time Physical Activity and Sex Differences.Journal of Korean medical science · 2026Article
- Food as Medicine for Hypertension: Microbiota as Mediators.Hypertension (Dallas, Tex. : 1979) · 2025Review
- Beverage Consumption in Reproductive-Age and Postmenopausal Mexican Women: Habits and Associated Factors.Foods (Basel, Switzerland) · 2025Article
- The Role of Hydration in Children and Adolescents-A Theoretical Framework for Reviewing Recommendations, Models, and Empirical Studies.Nutrients · 2025Review
- The Influence of Drinking Water Intake on Pollutant Levels in the Human Body: Evidence from NHANES Data.Life (Basel, Switzerland) · 2025Article
- The Impact of Hydration on Metabolic Outcomes: From Arginine-Vasopressin Signaling to Clinical Implications.Medicina (Kaunas, Lithuania) · 2025Review
- Potential Role of Dietary Antioxidants During Skin Aging.Food science & nutrition · 2025Review
- Apparently healthy young black adults report lower total fluid intake and exhibit higher plasma copeptin than young White adults.Nutrition research (New York, N.Y.) · 2025Article
- Medium-Term Effects of Increased Water Intake and Head-Up Sleep on Cardiovascular Health.JACC. Advances · 2025Article
- Association between plain water intake and the risk of osteoporosis among middle-aged and elderly people in the United States: a cross-sectional study.Frontiers in nutrition · 2025Article
- Association between hydration status and the risk and all-cause mortality of diabetic kidney disease.Renal failure · 2024Article
- Assessment of Dietary and Lifestyle Quality among the Romanian Population in the Post-Pandemic Period.Healthcare (Basel, Switzerland) · 2024Article
- Incidence of Urinary Infections and Behavioral Risk Factors.Nutrients · 2024Article
- Hydration status in adults with metabolic disorders in relation to socioeconomic, lifestyle and health factors.PloS one · 2024Article
- Analysis of the Influence of Socio-Demographic Variables and Some Nutrition and Lifestyle Habits on Beverage Consumption in the Spanish Population.Foods (Basel, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increased hydration is recommended as healthy habit with several merits. However, supportive data are sparse. To assess the efficacy of increased daily water intake, we tested the effect of water supplementation on biomarkers in blood, urine, and saliva. Twenty-four healthy Japanese men and 31 healthy Japanese women with fasting blood glucose levels ranging from 90-125 mg/dL were included. An open-label, two-arm, randomized controlled trial was conducted for 12 weeks. Two additional 550 mL bottles of water on top of habitual fluid intake were consumed in the intervention group. The subjects drank one bottle of water (550 mL) within 2 h of waking, and one bottle (550 mL) 2 h before bedtime. Subjects increased mean fluid intake from 1.3 L/day to 2.0 L/day, without changes in total energy intake. Total body water rate increased with associated water supplementation. There were no significant changes in fasting blood glucose and arginine vasopressin levels, but systolic blood pressure was significantly decreased in the intervention group. Furthermore, water supplementation increased body temperature, reduced blood urea nitrogen concentration, and suppressed estimated glomerular filtration rate reduction. Additionally, existence of an intestinal microbiome correlated with decreased systolic blood pressure and increased body temperature. Habitual water supplementation after waking up and before bedtime in healthy subjects with slightly elevated fasting blood glucose levels is not effective in lowering these levels. However, it represents a safe and promising intervention with the potential for lowering blood pressure, increasing body temperature, diluting blood waste materials, and protecting kidney function. Thus, increasing daily water intake could provide several health benefits.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.