ReviewPathogens (Basel, Switzerland)2020
Phenylpropanoid Pathway Engineering: An Emerging Approach towards Plant Defense.
Review in Pathogens (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 200 papers.
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Who cites it
200 citing papers in PubMed.
- Metabolic reprogramming in plant defense: linking signaling networks to metabolomics-driven insights.Plant signaling & behavior · 2026Review
- In-source freezing of Trifolium repens leaf tissue to increase spatial resolution and quench stress responses during IR-MALDESI mass spectrometry imaging.Analytical and bioanalytical chemistry · 2026Article
- Multi-Omics Analyses Reveal the Red and Far-Red Light Combination Enhancing Heterologous Protein and Metabolite Production in Nicotiana benthamiana.Plant, cell & environment · 2026Article
- Comparative Transcriptomic Analysis of Potato and Tomato Responses toPlants (Basel, Switzerland) · 2026Article
- Genome-Wide Identification of the PAL Gene Family inInternational journal of molecular sciences · 2026Article
- Integrative genetic and hormonal coordination of endocarp/stone development in drupe fruit.Horticulture research · 2026Review
- Hyperspectral imaging reveals early drought stress and associated molecular responses in lettuce for space agriculture.Plant phenomics (Washington, D.C.) · 2026Article
- Bacillus amyloliquefaciens-induced resistance against the olive knot disease: An integrated transcriptomic and metabolomic analysis.Pest management science · 2026Article
- Mesembryanthemum crystallinum -guided green synthesis of ZnO nanoparticles with selective anticancer activity via ROS-mediated mitochondrial dysfunction.Bioresources and bioprocessing · 2026Article
- Endophytic Bacterial Exopolysaccharide and Ethylene Hyperactivate Flavonoid Synthesis in Leaves ofPlants (Basel, Switzerland) · 2026Article
- Biostimulatory Effect of 3-Acetonyl-3-Hydroxyoxindole on the Growth and Secondary Metabolites ofInternational journal of molecular sciences · 2026Article
- Unveiling Dynamic Defense Pathways: Transcriptome Analysis of Phenylpropanoids and (Iso)flavonoids in Cowpea Leaves Post-CABMV Inoculation.Biochemical genetics · 2026Article
- Cinnamic acid derivatives in agrochemicals: current use and future perspective.Journal of advanced research · 2026Review
- The Dual Role of Lignin in Fruit Trees: Unraveling Regulatory Networks from Stress Resilience to Quality Control.Plants (Basel, Switzerland) · 2026Review
- Constitutive and inducible oleoresin defenses share genetic architectures and mechanisms in Pinus taeda.The New phytologist · 2026Article
- Enhanced Synthesis of Polyphenols and Terpenes by UV-A Irradiation inMetabolites · 2026Article
- Comprehensive UPLC-MS/MS Profiling of Bioactive Phenolics and Their MYB Regulatory Networks in Wild and Cultivated Strawberries.Molecules (Basel, Switzerland) · 2026Article
- Unraveling the metabolic regulation of Eleutherococcus senticosus leaves by Penicillium oxalicum: insights from targeted and non-targeted metabolomics.BMC plant biology · 2026Article
- Plant Immunometabolism: Metabolic Reprogramming Linking Developmental Signaling and Defense Metabolites.International journal of molecular sciences · 2026Review
- Temporal Metabolic Reprogramming Reveals Stage-Specific Adaptations in Proso Millet Resistance Against Head Smut.Metabolites · 2026Article
140 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Pathogens hitting the plant cell wall is the first impetus that triggers the phenylpropanoid pathway for plant defense. The phenylpropanoid pathway bifurcates into the production of an enormous array of compounds based on the few intermediates of the shikimate pathway in response to cell wall breaches by pathogens. The whole metabolomic pathway is a complex network regulated by multiple gene families and it exhibits refined regulatory mechanisms at the transcriptional, post-transcriptional, and post-translational levels. The pathway genes are involved in the production of anti-microbial compounds as well as signaling molecules. The engineering in the metabolic pathway has led to a new plant defense system of which various mechanisms have been proposed including salicylic acid and antimicrobial mediated compounds. In recent years, some key players like phenylalanine ammonia lyases (PALs) from the phenylpropanoid pathway are proposed to have broad spectrum disease resistance (BSR) without yield penalties. Now we have more evidence than ever, yet little understanding about the pathway-based genes that orchestrate rapid, coordinated induction of phenylpropanoid defenses in response to microbial attack. It is not astonishing that mutants of pathway regulator genes can show conflicting results. Therefore, precise engineering of the pathway is an interesting strategy to aim at profitably tailored plants. Here, this review portrays the current progress and challenges for phenylpropanoid pathway-based resistance from the current prospective to provide a deeper understanding.
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Registered trials
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