ReviewNutrients2020
Intestinal Permeability, Inflammation and the Role of Nutrients.
Review in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 130 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
130 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Effect of multistrain probiotics on symptom severity in irritable bowel syndrome: a systematic review and meta-analysis of irritable bowel syndrome-symptom severity score outcomes.European journal of gastroenterology & hepatology · 2026Pooled it
- Intestinal permeability in human cardiovascular diseases: a systematic review and meta-analysis.Frontiers in nutrition · 2024Pooled it
- Dietary Polyphenols and In Vitro Intestinal Fructose Uptake and Transport: A Systematic Literature Review.International journal of molecular sciences · 2022Pooled it
- Effect of Ibuprofen on Markers of Acute Kidney Injury, Intestinal Injury, and Endotoxemia after Running in the Heat.Medicine and science in sports and exercise · 2025Trial
- Weight loss via a low-carbohydrate diet improved the intestinal permeability marker, zonulin, in prostate cancer patients.Annals of medicine · 2022Trial
- Provision of small-quantity lipid-based nutrient supplements does not improve intestinal health among rural Malawian children.Maternal & child nutrition · 2022Trial
- Effects of a Chemically Characterised Multi-Component Nutraceutical Formulation on Intestinal, Hepatic and Skeletal Muscle Responses in an In Vitro Gut-Liver-Muscle Model.International journal of molecular sciences · 2026Article
- Treg/Th Cell Imbalance Is Negatively Associated with Gut Microbiota Dysbiosis and Growth Impairment in Children Exposed to PFAS, PAHs, and Phthalates.Environment & health (Washington, D.C.) · 2026Article
- Prevalence and Correlates of Environmental Enteric Dysfunction Among Young Children in Bangladesh.Maternal & child nutrition · 2026Article
- Painful gastric glitch: an acute epigastric pain triggered by specific food as a new phenotype of postprandial epigastric pain syndrome.BMC gastroenterology · 2026Article
- Role of itaconate in intestinal disease (Review).International journal of molecular medicine · 2026Review
- Live tissue microbiota and bacterial translocation: mechanisms and translational perspectives in cardiometabolic diseases.Reviews in endocrine & metabolic disorders · 2026Review
- Regulatory mechanisms of Traditional Chinese Medicine on gut microbiota in diabetic microvascular complications.Chinese medicine · 2026Review
- Age-Dependent Increase in Small Intestinal Permeability and Sex-Dependent Absorptive Capacity in Cats (Felis catus).Journal of animal physiology and animal nutrition · 2026Article
- Trace mineral sources affect oxidized oil induced intestinal damage in chickens by modulation of gut microbiota and short-chain fatty acid metabolism.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Gut microbiota and intestinal permeability in rheumatoid arthritis: pathogenic mechanisms.Frontiers in immunology · 2026Review
- Gut microbiota orchestrates bone homeostasis: a multi-pathway network from intestine to skeleton.Frontiers in endocrinology · 2026Review
- Low-Fat Cheddar Cheese Influences Gut Microbiota Composition and Diversity in Human Microbiota-Associated Mice.Foods (Basel, Switzerland) · 2025Article
- Protective Effects of Tributyrin on Cyclic Heat-Stressed Taihe Silky Fowls: Insights into Oxidative Status, Inflammatory Response, and Mucosal Barrier Function.Antioxidants (Basel, Switzerland) · 2025Article
- Extra-oral expression of bitter taste receptors in pigs and their correlation with hepatic cytochrome P450 enzymes.Cell and tissue research · 2025Article
70 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The interaction between host and external environment mainly occurs in the gastrointestinal tract, where the mucosal barrier has a critical role in many physiologic functions ranging from digestion, absorption, and metabolism. This barrier allows the passage and absorption of nutrients, but at the same time, it must regulate the contact between luminal antigens and the immune system, confining undesirable products to the lumen. Diet is an important regulator of the mucosal barrier, and the cross-talk among dietary factors, the immune system, and microbiota is crucial for the modulation of intestinal permeability and for the maintenance of gastrointestinal tract (GI) homeostasis. In the present review, we will discuss the role of a number of dietary nutrients that have been proposed as regulators of inflammation and epithelial barrier function. We will also consider the metabolic function of the microbiota, which is capable of elaborating the diverse nutrients and synthesizing products of great interest. Better knowledge of the influence of dietary nutrients on inflammation and barrier function can be important for the future development of new therapeutic approaches for patients with mucosal barrier dysfunction, a critical factor in the pathogenesis of many GI and non-GI diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.