Evidence map›Paper›PMID 32340176›Full record

ArticleCancers2020

Targeted Next-Generation Sequencing of 117 Routine Clinical Samples Provides Further Insights into the Molecular Landscape of Uveal Melanoma.

Sophie Thornton, Sarah E Coupland, Lisa Olohan, Julie S Sibbring, John G Kenny, Christiane Hertz-Fowler, Xuan Liu, Sam Haldenby, Heinrich Heimann, Rumana Hussain and 3 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Article
  4. Article
  5. Review
  6. Co-occurrence ofAmerican journal of ophthalmology case reports · 2025
    Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Cancers · 2022
    Review
  18. Vascular Lakes in Uveal Melanoma and Their Association With Outcome.Translational vision science & technology · 2022
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Sophie ThorntonLiverpool Ocular Oncology Research Group, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool L7 8XT, UK.ORCID 0000-0001-7693-7279
Sarah E CouplandLiverpool Ocular Oncology Research Group, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool L7 8XT, UK.
Lisa OlohanCentre for Genomic Research, Institute of Integrative Biology, University of Liverpool, Liverpool L69 7BT, UK.
Julie S SibbringCentre for Genomic Research, Institute of Integrative Biology, University of Liverpool, Liverpool L69 7BT, UK.ORCID 0000-0001-9178-6851
John G KennyCentre for Genomic Research, Institute of Integrative Biology, University of Liverpool, Liverpool L69 7BT, UK.ORCID 0000-0003-2994-6169
Christiane Hertz-FowlerCentre for Genomic Research, Institute of Integrative Biology, University of Liverpool, Liverpool L69 7BT, UK.
Xuan LiuCentre for Genomic Research, Institute of Integrative Biology, University of Liverpool, Liverpool L69 7BT, UK.
Sam HaldenbyCentre for Genomic Research, Institute of Integrative Biology, University of Liverpool, Liverpool L69 7BT, UK.
Heinrich HeimannSt. Paul's Eye Unit, Liverpool University Hospitals NHS Foundation Trust, Liverpool L7 8XP, UK.
Rumana HussainSt. Paul's Eye Unit, Liverpool University Hospitals NHS Foundation Trust, Liverpool L7 8XP, UK.
Natalie KiplingLiverpool Clinical Laboratories, Liverpool University Hospitals NHS Foundation Trust, Liverpool L69 3GA, UK.
Azzam TaktakDepartment of Medical Physics and Clinical Engineering, Liverpool University Hospitals NHS Foundation Trust, 1st Floor Duncan Building, Liverpool L7 8XP, UK.
Helen KaliraiLiverpool Ocular Oncology Research Group, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool L7 8XT, UK.
University of Liverpool · GB

Funding

The Eye Tumour Research Fund A091/CFThe Liverpool Health Genomics Healthcare Laboratory N/A
6 · The paper itself

Abstract

Uveal melanoma (UM) has well-characterised somatic copy number alterations (SCNA) in chromosomes 1, 3, 6 and 8, in addition to mutations in

Indexed as

chromosomeclinical samplescopy numbermutationnext-generation sequencingprognosticationuveal melanoma

Identifiers

PMID32340176
PMCPMC7226611
OpenAlexW3017903297

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.