Evidence map›Paper›PMID 32339990›Full record

ArticleiScience2020

ER Stress Regulates Immunosuppressive Function of Myeloid Derived Suppressor Cells in Leprosy that Can Be Overcome in the Presence of IFN-γ.

Kindra M Kelly-Scumpia, Aaron Choi, Roksana Shirazi, Hannah Bersabe, Esther Park, Philip O Scumpia, Maria T Ochoa, Jing Yu, Feiyang Ma, Matteo Pellegrini and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Dual roles of CD11bFrontiers in immunology · 2024
    Article
  3. Review
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Kindra M Kelly-ScumpiaDivision of Dermatology, David Geffen School of Medicine, Los Angeles, CA 90095, USA. Electronic address: kkellyscumpia@mednet.ucla.edu.
Aaron ChoiDepartment of Molecular, Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA.
Roksana ShiraziDivision of Dermatology, David Geffen School of Medicine, Los Angeles, CA 90095, USA.
Hannah BersabeDepartment of Molecular, Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA.
Esther ParkDepartment of Molecular, Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA.
Philip O ScumpiaDivision of Dermatology, David Geffen School of Medicine, Los Angeles, CA 90095, USA.
Maria T OchoaDepartment of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Jing YuDepartment of Molecular, Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA.
Feiyang MaDepartment of Molecular, Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA.
Matteo PellegriniDepartment of Molecular, Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA.
Robert L ModlinDivision of Dermatology, David Geffen School of Medicine, Los Angeles, CA 90095, USA; Department of Molecular, Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA.
University of California, Los Angeles · USUniversity of Southern California · US

Funding

Molecular Analysis of the Host Immune Response in LeprosyR01AI022553 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROBERT L MODLIN · 1989 to 2026
$15.7M
TCR GAMMA/DELTA LYMPHOCYTES IN HUMAN SKIN LESIONSR01AR040312 · NIAMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MODLIN, ROBERT L · 1990 to 2025
$10.4M
IL-26 in host defense against infection by intracellular bacteria in skinR01AR073252 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MODLIN, ROBERT L · 2019 to 2023
$2.1M
IL-34 regulation of cutaneous immunity by polarizing myeloid cell differentiationK01AR070911 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KELLY-SCUMPIA, KINDRA · 2017 to 2021
$688k
NIAID NIH HHS R01 AI022553NIAMS NIH HHS K01 AR070911NIAMS NIH HHS R01 AR040312NIAMS NIH HHS R01 AR073252
6 · The paper itself

Abstract

Myeloid derived suppressor cells (MDSCs) are a population of immature myeloid cells that suppress adaptive immune function, yet the factors that regulate their suppressive function in patients with infection remain unclear. We studied MDSCs in patients with leprosy, a disease caused by Mycobacterium leprae, where clinical manifestations present on a spectrum that correlate with immunity to the pathogen. We found that HLA-DR

Indexed as

Biological SciencesCell BiologyFunctional Aspects of Cell BiologyImmune ResponseImmunology

Identifiers

PMID32339990
PMCPMC7190750
OpenAlexW3016101385

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.