Evidence map›Paper›PMID 32339711›Full record

ArticleActa biomaterialia2020

Collagen fibril abnormalities in human and mice abdominal aortic aneurysm.

Blain Jones, Jeffrey R Tonniges, Anna Debski, Benjamin Albert, David A Yeung, Nikhit Gadde, Advitiya Mahajan, Neekun Sharma, Edward P Calomeni, Michael R Go and 2 more

Open access · greenAbstract read
In one paragraph

Article in Acta biomaterialia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Operational Standard for Tissue-Extracted Collagen Facial Injection Techniques.Clinical, cosmetic and investigational dermatology · 2026
    Article
  3. Nano-mechanical mapping of human and porcine abdominal aortic aneurysm.Journal of the mechanical behavior of biomedical materials · 2026
    Article
  4. Aneurysm Is Restricted by CD34Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. A Fast, Robust Method for Quantitative Assessment of Collagen Fibril Architecture from Transmission Electron Micrographs.Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada · 2023
    Article
  12. Article
  13. The Chemistry and Biology of Collagen Hybridization.Journal of the American Chemical Society · 2023
    Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Mechanosignals in abdominal aortic aneurysms.Frontiers in cardiovascular medicine · 2022
    Review
  19. Regional biomechanical and failure properties of healthy human ascending aorta and root.Journal of the mechanical behavior of biomedical materials · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Blain JonesDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH, USA.
Jeffrey R TonnigesBiophysics Graduate Program, The Ohio State University, Columbus, OH, USA.
Anna DebskiDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH, USA.
Benjamin AlbertDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH, USA.
David A YeungDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH, USA.
Nikhit GaddeDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH, USA.
Advitiya MahajanCenter for Cardiovascular Research, Nationwide Children's Hospital, Columbus, OH, USA; Department of Cardiovascular Medicine, Dalton Cardiovascular Research Center, and Medical Pharmacology and Physiology Columbia, University of Missouri, USA.
Neekun SharmaDepartment of Cardiovascular Medicine, Dalton Cardiovascular Research Center, and Medical Pharmacology and Physiology Columbia, University of Missouri, USA.
Edward P CalomeniDepartment of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Michael R GoDivision of Vascular Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Chetan P HansCenter for Cardiovascular Research, Nationwide Children's Hospital, Columbus, OH, USA; Department of Cardiovascular Medicine, Dalton Cardiovascular Research Center, and Medical Pharmacology and Physiology Columbia, University of Missouri, USA. Electronic address: hanscp@health.missouri.edu.
Gunjan AgarwalDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH, USA; Biophysics Graduate Program, The Ohio State University, Columbus, OH, USA. Electronic address: agarwal.60@osu.edu.
The Ohio State University · USNationwide Children's Hospital · USThe Ohio State University Wexner Medical Center · USUniversity of Missouri · US

Funding

Role of Notch1 Signaling in Abdominal Aortic AneurysmR01HL124155 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI HANS, CHETAN · 2015 to 2019
$1.9M
NHLBI NIH HHS R01 HL124155
6 · The paper itself

Abstract

Vascular diseases like abdominal aortic aneurysms (AAA) are characterized by a drastic remodeling of the vessel wall, accompanied with changes in the elastin and collagen content. At the macromolecular level, the elastin fibers in AAA have been reported to undergo significant structural alterations. While the undulations (waviness) of the collagen fibers is also reduced in AAA, very little is understood about changes in the collagen fibril at the sub-fiber level in AAA as well as in other vascular pathologies. In this study we investigated structural changes in collagen fibrils in human AAA tissue extracted at the time of vascular surgery and in aorta extracted from angiotensin II (AngII) infused ApoE

Indexed as

Aortic Aneurysm, AbdominalAngiotensin IIAnimalsAorta, AbdominalCollagenDisease Models, AnimalExtracellular MatrixHumansMiceMice, KnockoutAngiotensin IICollagenAbdominal aortic aneurysmAtomic force microscopyCollagenElectron microscopy

Identifiers

PMID32339711
PMCPMC7276293
OpenAlexW3018131218

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.