Evidence map›Paper›PMID 32339646›Full record

ArticleInternational journal of radiation oncology, biology, physics2020

Simultaneous Metabolic and Perfusion Imaging Using Hyperpolarized

Hecong Qin, Vickie Zhang, Robert A Bok, Romelyn Delos Santos, J Adam Cunha, I-Chow Hsu, Justin Delos Santos Bs, Jessie E Lee, Subramaniam Sukumar, Peder E Z Larson and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of radiation oncology, biology, physics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Hyperpolarized Carbon-13 MRI in Breast Cancer.Diagnostics (Basel, Switzerland) · 2023
    Review
  8. Review
  9. Article
  10. Signal enhancement of hyperpolarizedNMR in biomedicine · 2022
    Article
  11. Article
  12. Clinical translation of hyperpolarizedMagnetic resonance in medicine · 2022
    Article
  13. Review
  14. Review
  15. Oncoimmunology Meets Organs-on-Chip.Frontiers in molecular biosciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Hecong QinDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California; Graduate Program in Bioengineering, University of California, Berkeley and University of California, San Francisco, California.
Vickie ZhangDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California.
Robert A BokDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California.
Romelyn Delos SantosDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California.
J Adam CunhaDepartment of Radiation Oncology, University of California, San Francisco, California.
I-Chow HsuDepartment of Radiation Oncology, University of California, San Francisco, California.
Justin Delos Santos BsDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California.
Jessie E LeeDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California.
Subramaniam SukumarDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California.
Peder E Z LarsonDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California; Graduate Program in Bioengineering, University of California, Berkeley and University of California, San Francisco, California.
Daniel B VigneronDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California; Graduate Program in Bioengineering, University of California, Berkeley and University of California, San Francisco, California.
David M WilsonDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California.
Renuka SriramDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California.
John KurhanewiczDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California; Graduate Program in Bioengineering, University of California, Berkeley and University of California, San Francisco, California. Electronic address: john.kurhanewicz@ucsf.edu.
University of California, San Francisco · USUniversity of California, Berkeley · US

Funding

TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DUAN XU · 2011 to 2026
$19.9M
CLINICAL TRANSLATION OF HYPERPOLARIZED 13C-UREA FOR CANCER MR MOLECULAR IMAGINGR01CA214554 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KURHANEWICZ, JOHN, RUSCITTO, DANIEL MARTIN · 2017 to 2021
$3.3M
Novel Hyperpolarized MR Markers of Advanced Prostate Cancer TherapyR01CA166655 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KURHANEWICZ, JOHN, VIGNERON, DANIEL B · 2012 to 2016
$3.0M
Ascorbate-based biomarkers for predicting radiation response in prostate cancerR01CA166766 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WILSON, DAVID M · 2012 to 2016
$2.4M
NCI NIH HHS R01 CA166655NCI NIH HHS R01 CA166766NCI NIH HHS R01 CA214554NIBIB NIH HHS P41 EB013598
6 · The paper itself

Abstract

purposeTo investigate use of a novel imaging approach, hyperpolarized (HP) METHODS AND MATERIALS: Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) mice (n = 18) underwent single-fraction RT (4-14 Gy steep dose across the tumor) and were imaged serially at pre-RT baseline and 1, 4, and 7 days after RT using HP

resultsWe found a significant decrease in HP pyruvate-to-lactate conversion in tumors responding to RT, with concomitant significant increases in HP pyruvate-to-alanine conversion and HP urea signal; the opposite changes were observed in tumors resistant to RT. Moreover, HP lactate change was dependent on radiation dose; tumor regions treated with higher radiation doses (10-14 Gy) exhibited a greater decrease in HP lactate signal than low-dose regions (4-7 Gy) as early as 1 day post-RT, consistent with lactate dehydrogenase enzyme activity and expression data. We also found that HP [

conclusionThese results demonstrate the ability of HP

Indexed as

Magnetic Resonance ImagingPerfusion ImagingAnimalsCarbon IsotopesDisease Models, AnimalDose-Response Relationship, RadiationMaleMiceProstatic NeoplasmsPyruvic AcidTime FactorsTreatment OutcomeUreaCarbon-13Carbon IsotopesPyruvic AcidUrea

Identifiers

PMID32339646
PMCPMC7381368
OpenAlexW3019075491

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.