ArticlePLoS pathogens2020
Plant NLR immune receptor Tm-22 activation requires NB-ARC domain-mediated self-association of CC domain.
Article in PLoS pathogens, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 72 citations in OpenAlex.
- Pathogen Effector-Mediated Reprogramming of Plant Alternative Splicing: From Immune Regulation to Crop Disease Resistance.Plants (Basel, Switzerland) · 2026Review
- The durable resistance gene Tm-22 remains partially resistant to tomato brown rugose fruit virus.PLoS pathogens · 2026Article
- Tomato Brown Rugose Fruit Virus Evades Tm-2Molecular plant pathology · 2026Article
- Lipid Metabolism and Actin Cytoskeleton Regulation Underlie Yield and Disease Resistance in TwoPlants (Basel, Switzerland) · 2025Article
- A major and stable QTL confers impatiens necrotic spot virus resistance in lettuce cv. Eruption.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Engineering resistance genes against tomato brown rugose fruit virus.Science China. Life sciences · 2025Article
- Article
- Assessment of Self-Activation and Inhibition of Wheat Coiled-Coil Domain Containing NLR Immune Receptor Yr10Plants (Basel, Switzerland) · 2025Article
- OsBRW1, a novel blast-resistant gene, coded a NBS-LRR protein to interact with OsSRFP1 to balance rice growth and resistance.Plant biotechnology journal · 2025Article
- Crop antiviral defense: Past and future perspective.Science China. Life sciences · 2024Review
- Activation of an atypical plant NLR with an N-terminal deletion initiates cell death at the vacuole.EMBO reports · 2024Article
- Activation and Autoinhibition Mechanisms of NLR Immune Receptor Pi36 in Rice.International journal of molecular sciences · 2024Article
- The soybean plasma membrane GmDR1 protein conferring broad-spectrum disease and pest resistance regulates several receptor kinases and NLR proteins.Scientific reports · 2024Article
- Adaptive regulation of miRNAs/milRNAs in tissue-specific interaction between apple andHorticulture research · 2024Article
- Plant Immunity against Tobamoviruses.Viruses · 2024Review
- Rice NLR protein XinN1, induced by a pattern recognition receptor XA21, confers enhanced resistance to bacterial blight.Plant cell reports · 2024Article
- A plasma membrane nucleotide-binding leucine-rich repeat receptor mediates the recognition of the Ralstonia pseudosolanacearum effector RipY in Nicotiana benthamiana.Plant communications · 2023Article
- The Hypersensitive Response to Plant Viruses.Viruses · 2023Review
- Activation of Tm-2Molecular plant pathology · 2023Article
- Contribution of Duplicated Nucleotide-Binding Leucine-Rich Repeat (NLR) Genes to Wheat Disease Resistance.Plants (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nucleotide-binding, leucine-rich repeat-containing (NLR) class of immune receptors of plants and animals recognize pathogen-encoded proteins and trigger host defenses. Although animal NLRs form oligomers upon pathogen recognition to activate downstream signaling, the mechanisms of plant NLR activation remain largely elusive. Tm-22 is a plasma membrane (PM)-localized coiled coil (CC)-type NLR and confers resistance to Tobacco mosaic virus (TMV) by recognizing its viral movement protein (MP). In this study, we found that Tm-22 self-associates upon recognition of MP. The CC domain of Tm-22 is the signaling domain and its function requires PM localization and self-association. The nucleotide-binding (NB-ARC) domain is important for Tm-22 self-interaction and regulates activation of the CC domain through its nucleotide-binding and self-association. (d)ATP binding may alter the NB-ARC conformation to release its suppression of Tm-22 CC domain-mediated cell death. Our findings provide the first example of signaling domain for PM-localized NLR and insight into PM-localized NLR activation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.