ReviewCancer control : journal of the Moffitt Cancer Center
Locally Advanced Oral Cavity Cancers: What Is The Optimal Care?
Review in Cancer control : journal of the Moffitt Cancer Center. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Exploring lived experiences in oral cavity cancer: an Asia-Pacific perspective on psychosocial challenges and opportunities for enhanced patient-centric care.Journal of cancer survivorship : research and practice · 2026Article
- Comparative Evaluation of Upfront Surgery and Neoadjuvant Chemotherapy Followed by Surgery in Locally Advanced Oral Squamous Cell Carcinoma.Journal of maxillofacial and oral surgery · 2025Article
- Impact of Induction Chemotherapy Before Radical Chemoradiation in Oral Cavity Squamous Cell Carcinoma: A Tertiary Centre Experience.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025Article
- Locally Advanced oral Squamous cell Carcinomas: Auditing and Outcome Appraisal.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- Survival Outcomes and Factors Affecting Survival in Resectable Locally Advanced Oral Squamous Cell Carcinoma.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- Prevalence of locoregional recurrence and survival post-treatment of head and neck cancers in Africa: a systematic review and meta-analysis.EClinicalMedicine · 2023Article
- Oral health related quality of life of oral cancer patients treated with radiotherapy alone or with chemotherapy in a tertiary referral centre in Sri Lanka.BMC oral health · 2023Article
- Sociocultural adaptation, translation and pre-testing of the Kannada version of Vanderbilt Head and Neck Symptom Survey 2.0.Journal of patient-reported outcomes · 2022Article
- Neoadjuvant Chemoradiotherapy for Oral Cavity Cancer: Predictive Factors for Response and Interim Analysis of the Prospective INVERT-Trial.Frontiers in oncology · 2022Article
- Induction Chemotherapy for Advanced Oral Cavity Cancer.Current oncology reports · 2021Review
- Impact of the COVID-19 pandemic in the head and neck cancer treatment in the Brazil.Oral oncology · 2021Article
- Therapeutic Options in Unresectable Oral Squamous Cell Carcinoma: A Systematic Review.Cancer management and research · 2021Review
- Quality of life in Iranian patients with head-and-neck cancer.Journal of education and health promotion · 2020Article
- Clinical efficacy of highly agglutinative staphylococcin combined with neoadjuvant chemotherapy on patients with intermediate or advanced oral cancer.Pakistan journal of medical sciencesArticle
- Management and outcome of locally advanced oral squamous cell carcinoma.National journal of maxillofacial surgeryReview
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with oral cavity cancers often present late to seek medical care. Surgery is usually the preferred upfront treatment. However, surgical resection cannot be achieved in many cases with advanced disease without major impact on patient's quality of life. On the other hand, radiotherapy (RT) and chemotherapy (CT) have not been employed routinely to replace surgery as curative treatment or to facilitate surgery as neoadjuvant therapy. The optimal care of these patients is challenging when surgical treatment is not feasible. In this review, we aimed to summarize the best available evidence-based treatment approaches for patients with locally advanced oral cavity cancer. Surgery followed by RT with or without CT is the standard of care for locally advanced oral cavity squamous cell carcinoma. In the case of unresectable disease, induction CT prior to surgery or chemoradiotherapy (CRT) can be attempted with curative intent. For inoperable patients or when surgery is expected to result in poor functional outcome, patients may be candidates for possibly curative CRT or palliative RT with a focus on quality of life.
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