Evidence map›Paper›PMID 32338879›Full record

ArticleJournal of the American Chemical Society2020

Self-Assembly of Block Heterochiral Peptides into Helical Tapes.

Tara M Clover, Conor L O'Neill, Rajagopal Appavu, Giriraj Lokhande, Akhilesh K Gaharwar, Ammon E Posey, Mark A White, Jai S Rudra

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Substituent-Based Modulation of Self-Assembly and Immunogenicity of Amphipathic Peptides.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  7. Peptide Electrostatic Modulation Directs Human Neural Cell Fate.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Chirality Makes or Breaks Chemically Driven Self-Assembly.Angewandte Chemie (International ed. in English) · 2025
    Article
  12. Article
  13. Modulating Peptide Self-Assembly via Triblock Chiral Patterning.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  14. Chirality Effects in Peptide-Based Dynamic Combinatorial Chemistry.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tara M CloverDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.
Conor L O'NeillDepartment of Biomedical Engineering, McKelvey School of Engineering, Washington University in St. Louis, St. Louis, Missouri 63130, United States.ORCID 0000-0003-0714-8828
Rajagopal AppavuDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.
Giriraj LokhandeDepartment of Biomedical Engineering, Texas A&M University, College Station, Texas 77843, United States.
Akhilesh K GaharwarDepartment of Biomedical Engineering, Texas A&M University, College Station, Texas 77843, United States.ORCID 0000-0002-0284-0201
Ammon E PoseyDepartment of Biomedical Engineering, McKelvey School of Engineering, Washington University in St. Louis, St. Louis, Missouri 63130, United States.ORCID 0000-0002-1445-6522
Mark A WhiteSealy Center for Structural Biology and Molecular Biophysics and Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555, United States.ORCID 0000-0003-1057-4203
Jai S RudraDepartment of Biomedical Engineering, McKelvey School of Engineering, Washington University in St. Louis, St. Louis, Missouri 63130, United States.ORCID 0000-0002-7837-4980

Funding

TrainingP41GM103422 · NIGMS · WASHINGTON UNIVERSITY · PI YARASHESKI, KEVIN E · 2012 to 2019
$12.0M
Immunomodulatory Effects of Heterochiral BiomaterialsR01AI130278 · NIAID · WASHINGTON UNIVERSITY · PI RUDRA, JAI · 2018 to 2022
$1.8M
NIAID NIH HHS R01 AI130278NIGMS NIH HHS P41 GM103422
6 · The paper itself

Abstract

Patterned substitution of d-amino acids into the primary sequences of self-assembling peptides influences molecular-level packing and supramolecular morphology. We report that block heterochiral analogs of the model amphipathic peptide KFE8 (Ac-FKFEFKFE-NH

Indexed as

Amino Acid SequenceCircular DichroismHydrogelsPeptidesProtein Conformation, alpha-HelicalProtein Conformation, beta-StrandRheologyScattering, Small AngleStereoisomerismX-Ray DiffractionHydrogelsPeptides

Identifiers

PMID32338879
PMCPMC7606833

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.