Evidence map›Paper›PMID 32338831›Full record

ArticleChemMedChem2020

Rottlerin: Structure Modifications and KCNQ1/KCNE1 Ion Channel Activity.

Marco Lübke, Julian A Schreiber, Thang Le Quoc, Florian Körber, Jasmin Müller, Sivatharushan Sivanathan, Veronika Matschke, Janina Schubert, Nathalie Strutz-Seebohm, Guiscard Seebohm and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Cannabidiol inhibits both human KActa pharmacologica Sinica · 2026
    Article
  2. Kv7 Channels and Excitability Disorders.Handbook of experimental pharmacology · 2021
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Marco LübkeFaculty of Mathematics and Natural Sciences, University Wuppertal, 42119, Wuppertal, Germany.
Julian A SchreiberInstitut für Genetik von Herzerkrankungen, University Hospital Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.
Thang Le QuocDepartment of Chemistry, Hue University, 34 Le Loi St., Hue City, Vietnam.
Florian KörberFaculty of Mathematics and Natural Sciences, University Wuppertal, 42119, Wuppertal, Germany.
Jasmin MüllerFaculty of Mathematics and Natural Sciences, University Wuppertal, 42119, Wuppertal, Germany.
Sivatharushan SivanathanFaculty of Mathematics and Natural Sciences, University Wuppertal, 42119, Wuppertal, Germany.
Veronika MatschkeMedical Faculty, Institute of Anatomy Department of Cytology, Ruhr University Bochum, 44801, Bochum, Germany.
Janina SchubertInstitut für Genetik von Herzerkrankungen, University Hospital Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.
Nathalie Strutz-SeebohmInstitut für Genetik von Herzerkrankungen, University Hospital Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.
Guiscard SeebohmInstitut für Genetik von Herzerkrankungen, University Hospital Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.
Jürgen ScherkenbeckFaculty of Mathematics and Natural Sciences, University Wuppertal, 42119, Wuppertal, Germany.ORCID 0000-0003-1321-0595
University of Wuppertal · DEUniversity Hospital Münster · DEHue University · VNUniversity Hospitals of the Ruhr-University of Bochum · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The slow delayed rectifier potassium current (I

Indexed as

AcetophenonesAnimalsBenzopyransBinding SitesHumansKCNQ1 Potassium ChannelMolecular Docking SimulationOocytesPotassium Channels, Voltage-GatedProtein BindingXenopus laevisXenopus ProteinsAcetophenonesBenzopyransKCNE1 protein, XenopusKCNQ1 Potassium ChannelKCNQ1 protein, humanPotassium Channels, Voltage-GatedrottlerinXenopus Proteinsmode of actionnatural product rottlerinpotassium channel KCNQ1 activatortotal synthesis

Identifiers

PMID32338831
PMCPMC7318133
OpenAlexW3019990177

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.