ArticleeLife2020
A tudor domain protein, SIMR-1, promotes siRNA production at piRNA-targeted mRNAs in
Open access · goldAbstract read
In one paragraph
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 82 citations in OpenAlex.
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- Systematic Identification of Germ Granule Proteins Reveals Specialized Roles in RNAi and Small RNA Inheritance.bioRxiv : the preprint server for biology · 2026Article
- A SET domain-containing protein and HCF-1 maintain transgenerational epigenetic memory.Nature communications · 2026Article
- Germ granule localization of nematode Argonaute WAGO-4 ensures fidelity in small RNA loading.The EMBO journal · 2025Article
- TurboID-based proximity labeling identifies novel germline proteins that maintain E granule integrity and small RNA homeostasis in C. elegans.Science China. Life sciences · 2025Article
- RG motifs promote piRNA-mediated gene silencing in C. elegans.Nucleic acids research · 2025Article
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- A systems toxicology approach implicates post-transcriptional regulatory networks in reproductive defects from PFAS exposure.Toxicological sciences : an official journal of the Society of Toxicology · 2025Article
- A nuclear pore-anchored condensate enables germ granule organization and transgenerational epigenetic inheritance.Nature structural & molecular biology · 2025Article
- Intrinsically disordered arginine-glycine repeat domains tune sub-nucleolar compartmentalization in Caenorhabditis elegans.Genetics · 2025Article
- WAGO-1 is a sexually dimorphic Argonaute protein required for proper germ granule structure and gametogenesis.bioRxiv : the preprint server for biology · 2025Article
- Nucleoporins shape germ granule architecture and balance small RNA silencing pathways.Nature communications · 2025Article
- FG repeats drive co-clustering of nuclear pores and P granules in the C. elegans germline.Development (Cambridge, England) · 2025Article
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Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 2 countries.
Kevin I ManageDepartment of Biological Sciences, University of Southern California, Los Angeles, United States.ORCID 0000-0003-1992-0782
Alicia K RogersDepartment of Biological Sciences, University of Southern California, Los Angeles, United States.ORCID 0000-0001-5525-6095
Dylan C WallisDepartment of Biological Sciences, University of Southern California, Los Angeles, United States.ORCID 0000-0003-2375-5062
Celja J UebelDepartment of Biological Sciences, University of Southern California, Los Angeles, United States.ORCID 0000-0002-0362-1238
Dorian C AndersonDepartment of Biological Sciences, University of Southern California, Los Angeles, United States.
Dieu An H NguyenDepartment of Biological Sciences, University of Southern California, Los Angeles, United States.ORCID 0000-0003-4927-7329
Katerina ArcaDepartment of Biological Sciences, University of Southern California, Los Angeles, United States.
Kristen C BrownDepartment of Biology, Colorado State University, Fort Collins, United States.ORCID 0000-0002-5495-3371
Ricardo J Cordeiro RodriguesBiology of Non-coding RNA Group, Institute of Molecular Biology, Mainz, Germany.
Bruno Fm de AlbuquerqueBiology of Non-coding RNA Group, Institute of Molecular Biology, Mainz, Germany.ORCID 0000-0001-8483-6822
René F KettingBiology of Non-coding RNA Group, Institute of Molecular Biology, Mainz, Germany.ORCID 0000-0001-6161-5621
Taiowa A MontgomeryDepartment of Biology, Colorado State University, Fort Collins, United States.ORCID 0000-0001-7857-3253
Carolyn Marie PhillipsDepartment of Biological Sciences, University of Southern California, Los Angeles, United States.ORCID 0000-0002-6228-6468
University of Southern California · USInstitute of Molecular Biology · DEColorado State University · US
Funding
Regulation of gene expression and genome organization by small RNAsR35GM119656 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Carolyn Marie Phillips · 2016 to 2026
$5.3MMechanism and function of small RNAs in development and gene silencing in the germlineR35GM119775 · NIGMS · COLORADO STATE UNIVERSITY · PI Taiowa Akoni Montgomery · 2016 to 2026
$4.3MCBI: Chemistry Biology InterfaceT32GM118289 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FORSBURG, SUSAN L · 2016 to 2020
$1.2MSilencing of Mobile Genetic Elements by Small RNAsK22CA177897 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PHILLIPS, CAROLYN MARIE · 2014 to 2016
$575kDeutsche Forschungsgemeinschaft KE1888/1-1Deutsche Forschungsgemeinschaft KE1888/1-2National Science Foundation DGE 1418060NCI NIH HHS K22 CA177897NIGMS NIH HHS R35 GM119656NIGMS NIH HHS R35 GM119775NIGMS NIH HHS T32 GM118289
Abstract
piRNAs play a critical role in the regulation of transposons and other germline genes. In
Indexed as
AnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsFemaleMaleRNA, MessengerRNA, Small InterferingTudor DomainCaenorhabditis elegans ProteinsRNA, MessengerRNA, Small InterferingC. eleganschromosomesgene expressiongerm granulesgermlinenuagepiRNAsRNA silencingsiRNAs
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.