Evidence map›Paper›PMID 32338593›Full record

ArticleeLife2020

Chromatin accessibility dynamics and single cell RNA-Seq reveal new regulators of regeneration in neural progenitors.

Anneke Dixie Kakebeen, Alexander Daniel Chitsazan, Madison Corinne Williams, Lauren M Saunders, Andrea Elizabeth Wills

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 64 citations in OpenAlex.

  1. Article
  2. Article
  3. Spinal Cord Regeneration in Xenopus.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Shh signaling directs dorsal ventral patterning in the regeneratingbioRxiv : the preprint server for biology · 2024
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Regulation of chromatin organization during animal regeneration.Cell regeneration (London, England) · 2023
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Anneke Dixie KakebeenDepartment of Biochemistry, University of Washington, Seattle, United States.ORCID 0000-0002-4268-3028
Alexander Daniel ChitsazanOregon Health Sciences Center For Early Detection Advanced Research Center (CEDAR), Portland, United States.
Madison Corinne WilliamsDepartment of Biochemistry, University of Washington, Seattle, United States.
Lauren M SaundersDepartment of Genome Sciences, University of Washington, Seattle, United States.ORCID 0000-0003-4377-4252
Andrea Elizabeth WillsDepartment of Biochemistry, University of Washington, Seattle, United States.ORCID 0000-0003-3647-8105
University of Washington · US

Funding

TRAINING IN MOLECULAR AND CELLULAR BIOLOGYT32GM007270 · NIGMS · UNIVERSITY OF WASHINGTON · PI RAIBLE, DAVID W · 1985 to 2020
$21.0M
Transcriptional regulatory mechanisms of vertebrate regenerationR01NS099124 · NINDS · UNIVERSITY OF WASHINGTON · PI Andrea Elizabeth Wills · 2017 to 2026
$3.3M
NIGMS NIH HHS T32 GM007270NINDS NIH HHS R01 NS099124
6 · The paper itself

Abstract

Vertebrate appendage regeneration requires precisely coordinated remodeling of the transcriptional landscape to enable the growth and differentiation of new tissue, a process executed over multiple days and across dozens of cell types. The heterogeneity of tissues and temporally-sensitive fate decisions involved has made it difficult to articulate the gene regulatory programs enabling regeneration of individual cell types. To better understand how a regenerative program is fulfilled by neural progenitor cells (NPCs) of the spinal cord, we analyzed

Indexed as

Gene Expression Regulation, DevelopmentalAnimalsCell DifferentiationChromatinFemaleGene Expression ProfilingHomeodomain ProteinsMyeloid Ecotropic Viral Integration Site 1 ProteinNeural Stem CellsPAX6 Transcription FactorProto-Oncogene ProteinsRegenerationRNA-SeqSingle-Cell AnalysisSpinal CordTailChromatinHomeodomain ProteinsMyeloid Ecotropic Viral Integration Site 1 ProteinPAX6 Transcription Factorproto-oncogene protein Pbx3Proto-Oncogene ProteinsATAC-Seqdevelopmental biologyneural progenitor cellsregenerationregenerative medicinescRNA-Seqspinal cordstem cellsxenopusXenopus tropicalis

Identifiers

PMID32338593
PMCPMC7250574
OpenAlexW3018858044

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.