ArticleObesity surgery2020
Changes of Resting Energy Expenditure in Type 2 Diabetes Rats After Roux-en-Y Gastric Bypass.
Article in Obesity surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 3 citations in OpenAlex.
- The effect of aging on glucose metabolism improvement after Roux-en-Y gastric bypass in type 2 diabetes rats.Nutrition & diabetes · 2022Article
- Metabolic surgery in China: present and future.Journal of molecular cell biology · 2021Article
- Biliary diversion increases resting energy expenditure leading to decreased blood glucose level in mice with type 2 diabetes.Journal of diabetes investigation · 2021Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to investigate the changes of resting energy expenditure (REE) induced by Roux-en-Y gastric bypass (RYGB) in diabetic rats.
methodsThirty male Goto-Kakizaki rats were randomly divided into RYGB, sham RYGB (SR), and control groups. Glucose metabolism, energy expenditure, triiodothyronine, and bile acid levels were measured. Body composition in different groups was compared after sacrifice.
resultsRYGB induced significant diabetic improvement, with decreased maximum food intake and body weight. There was no significant difference in the REE between the groups before surgery (P = 0.74), while the REE of the RYGB group (1.15 ± 0.17 ml/h/g) was higher than that of the SR group (0.99 ± 0.13 ml/h/g) and the control group (0.97 ± 0.13 ml/h/g, P = 0.031) at the 20th postoperative week. The ratio of white adipose tissue in the RYGB group was lower (P = 0.02), and the ratio of brown adipose tissue was higher than that of the SR group and the control group (P = 0.045). Moreover, a higher bile acid level was detected in the RYGB group (6.4 ± 1.8 μmol/L) than in the SR group (4.2 ± 1.7 μmol/L) and the control group (4.0 ± 2.0 μmol/L, P = 0.025).
conclusionsRYGB induces a higher REE level in diabetic rats. The circulating bile acid level was enhanced after surgery.
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