Evidence map›Paper›PMID 32338123›Full record

SynthesisUpsala journal of medical sciences2020

DuoStim - a reproducible strategy to obtain more oocytes and competent embryos in a short time-frame aimed at fertility preservation and IVF purposes. A systematic review.

Alberto Vaiarelli, Danilo Cimadomo, Cecilia Petriglia, Alessandro Conforti, Carlo Alviggi, Nicolò Ubaldi, Sergio Ledda, Susanna Ferrero, Laura Rienzi, Filippo Maria Ubaldi

Registry-linked trialAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Upsala journal of medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05815719 (Continuous Ovarian Stimulation in DUOSTIM Cycles.), which is not on this map. Cited by 27 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05815719 phase4completednot on this mapstarted 2022, after this paper: background citation

Continuous Ovarian Stimulation in DUOSTIM Cycles.

TypeinterventionalSponsorInstituto BernabeuRan2022 to 2023Enrolled30ConditionsFertility IssuesArmsCorifollitropin Alfa, Follitropin Alfa, Follitropin Alfa Biosimilar, Urinary Human follicle stimulating hormone
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Luteal phase stimulation versus follicular phase stimulation in poor ovarian responders: A systematic review and a meta-analysis.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Observational
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Ovarian stimulation by promoting basal follicular growth.Reproductive biology and endocrinology : RB&E · 2025
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alberto VaiarelliClinica Valle Giulia, G.EN.E.R.A. Centers for Reproductive Medicine, Rome, Italy.
Danilo CimadomoClinica Valle Giulia, G.EN.E.R.A. Centers for Reproductive Medicine, Rome, Italy.
Cecilia PetrigliaDepartment of Obstetrics and Gynecology, University of Cagliari, Policlinico Universitario Duilio Casula, Monserrato, Cagliari, Italy.
Alessandro ConfortiDepartment of Neuroscience, Reproductive Science and Odontostomatology, University of Naples Federico II, Naples, Italy.
Carlo AlviggiDepartment of Neuroscience, Reproductive Science and Odontostomatology, University of Naples Federico II, Naples, Italy.
Nicolò UbaldiCatholic University of the Sacred Heart, Rome, Italy.
Sergio LeddaDepartment of Veterinary Medicine, University of Sassari, Sassari, Italy.
Susanna FerreroClinica Valle Giulia, G.EN.E.R.A. Centers for Reproductive Medicine, Rome, Italy.
Laura RienziClinica Valle Giulia, G.EN.E.R.A. Centers for Reproductive Medicine, Rome, Italy.
Filippo Maria UbaldiClinica Valle Giulia, G.EN.E.R.A. Centers for Reproductive Medicine, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent evidence suggests that follicular development occurs in a wave-like model during the ovarian cycle, where up to three cohorts of follicles are recruited to complete folliculogenesis. This understanding overtakes the previous dogma stating that follicles grow only during the follicular phase of the menstrual cycle. Therefore, in

Indexed as

Clinical ProtocolsFertility PreservationFertilization in VitroHumansOutcome Assessment, Health CareOvulation InductionAdvanced maternal ageBologna criteriadouble ovarian stimulationDuoStimfertility preservationPGTpoor-prognosis patientspoor-responder patientsreduced ovarian reserve

Identifiers

PMID32338123
PMCPMC7721001

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.