ArticleJournal of the American Chemical Society2020
Total Synthesis of (-)-Maximiscin.
Article in Journal of the American Chemical Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed.
- Visible Light-Mediated Direct Decarboxylative Giese Amidations without a Photocatalyst─Batch and Flow.The Journal of organic chemistry · 2026Article
- [1,2]-Carbon to Carbon Silyl Migration for Accessing α-Silyl Alkanals from α-Hydroxy Allyl Silanes.The Journal of organic chemistry · 2026Article
- Transition Metal-Catalyzed Direct C(spChemical reviews · 2026Review
- Application of Hosomi-Sakurai allylation reaction in total synthesis of biologically active natural products.Frontiers in chemistry · 2025Review
- Light-Mediated Direct Decarboxylative Giese Aroylations without a Photocatalyst.The Journal of organic chemistry · 2024Article
- A Comprehensive Review on Electrocatalytic Applications of 2D Metallenes.Nanomaterials (Basel, Switzerland) · 2023Review
- Direct decarboxylative Giese amidations: photocatalyticChemical science · 2023Article
- Highly Enantioselective Catalytic Lactonization at Nonactivated Primary and SecondaryJournal of the American Chemical Society · 2023Article
- Azoarene activation for Schmidt-type reaction and mechanistic insights.Nature communications · 2022Article
- Chimeric natural products derived from medermycin and the nature-inspired construction of their polycyclic skeletons.Nature communications · 2022Article
- Computational Prediction and Experimental Validation of a Bridged Cation Intermediate in Akanthomycin Biosynthesis.Journal of the American Chemical Society · 2022Article
- Working at the interfaces of data science and synthetic electrochemistry.Tetrahedron chem · 2022Article
- Electrocatalysis as an enabling technology for organic synthesis.Chemical Society reviews · 2021Article
- Ideality in Context: Motivations for Total Synthesis.Accounts of chemical research · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
A short, enantioselective synthesis of (-)-maximiscin, a structurally intriguing metabolite of mixed biosynthetic origin, is reported. A retrosynthetic analysis predicated on maximizing ideality and efficiency led to several unusual disconnections and tactics. Formation of the central highly oxidized pyridone ring through a convergent coupling at the end of the synthesis simplified the route considerably. The requisite building blocks could be prepared from feedstock materials (derived from shikimate and mesitylene). Strategies rooted in hidden symmetry recognition, C-H functionalization, and radical retrosynthesis played key roles in developing this concise route.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.