ArticleClinical and experimental immunology1988
Eosinophilic gastroenteritis: ultrastructural evidence for a selective release of eosinophil major basic protein.
Article in Clinical and experimental immunology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 117 citations in OpenAlex.
- Development of a suspension array assay in multiplex for the simultaneous measurement of serum levels of four eosinophil granule proteins.Journal of immunological methods · 2014Trial
- Eosinophilic Gastroenteritis: Clinical Manifestation, Natural Course, and Evaluation of Treatment with Corticosteroids and Vedolizumab.Digestive diseases and sciences · 2019Article
- Eosinophilic gastroenteritis: diagnosis and clinical perspectives.Clinical and experimental gastroenterology · 2019Review
- Diagnosis, Natural History and Treatment of Eosinophilic Enteritis: a Review.Current gastroenterology reports · 2018Review
- Contemporary understanding of the secretory granules in human eosinophils.Journal of leukocyte biology · 2018Review
- Oxaliplatin-induced changes in microbiota, TLR4+ cells and enhanced HMGB1 expression in the murine colon.PloS one · 2018Article
- Food-Induced Acute Pancreatitis.Digestive diseases and sciences · 2017Review
- Lung Pathologies in a Chronic Inflammation Mouse Model Are Independent of Eosinophil Degranulation.American journal of respiratory and critical care medicine · 2017Article
- Eosinophilic gastroenteritis: Approach to diagnosis and management.World journal of gastrointestinal pharmacology and therapeutics · 2016Review
- Eosinophilic Gastroenteritis and Colitis: a Comprehensive Review.Clinical reviews in allergy & immunology · 2016Review
- Elements Involved In Promoting Eosinophilic Gastrointestinal Disorders.Journal of genetic syndromes & gene therapy · 2015Article
- Eosinophilic gastrointestinal diseases: review and update.ISRN gastroenterology · 2012Article
- Piecemeal degranulation in human eosinophils: a distinct secretion mechanism underlying inflammatory responses.Histology and histopathology · 2010Review
- Enterolithiasis complicating eosinophilic enteritis: A case report and review of literature.World journal of gastrointestinal surgery · 2009Article
- Vesicle-mediated secretion of human eosinophil granule-derived major basic protein.Laboratory investigation; a journal of technical methods and pathology · 2009Article
- Gastrointestinal eosinophilia.Immunology and allergy clinics of North America · 2007Review
- Eosinophilic gastroenteritis and citrus-induced urticaria.Clinical reviews in allergy & immunology · 2006Article
- Eosinophilic gastroenteritis: a problem of the mucosal immune system?Current allergy and asthma reports · 2003Review
- Eosinophilic esophagitis: an emerging clinicopathologic entity.Current allergy and asthma reports · 2002Review
- Activated eosinophils and interleukin 5 expression in early recurrence of Crohn's disease.Gut · 1995Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ultrastructural study of mucosal eosinophils in a case of eosinophilic gastroenteritis involving stomach, duodenum and ileum showed an altered structure in ulcerated duodenal areas. The electron core density of eosinophil granules was inverted or disappeared and tubulovesicular structures occurred. Using immunogold staining with specific antibodies, major basic protein was detected diffusely in the matrix of eosinophil granules and out of the granules in tight association with extragranular membrane formations. In contrast, eosinophil cationic protein and eosinophil peroxidase were normally distributed in the granule matrix. When compared with the eosinophils in macroscopically normal duodenal mucosa in the same patient, these changes support a role for major basic protein in tissue damage in eosinophilic gastroenteritis. The diffusion of one granule protein from the granules to the exterior of the cells favours the view of a selective release of eosinophil mediators.
Indexed as
Identifiers
3233790PMC1542005W1445925What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.