Evidence map›Paper›PMID 32337831›Full record

ArticleJournal of cellular and molecular medicine2020

Polysaccharides from Dicliptera chinensis ameliorate liver disturbance by regulating TLR-4/NF-κB and AMPK/Nrf2 signalling pathways.

Kefeng Zhang, Qiongmei Xu, Ya Gao, Houkang Cao, Yuanyu Lian, Zimeng Li, Jie Xu, Mingli Zhong, Jiani Li, Riming Wei and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Kefeng ZhangCollege of Pharmacy, Guilin Medical University, Guilin, China.
Qiongmei XuCollege of Pharmacy, Guilin Medical University, Guilin, China.
Ya GaoCollege of Pharmacy, Guilin Medical University, Guilin, China.
Houkang CaoCollege of Pharmacy, Gansu University of Chinese Medicine, Lanzhou, China.
Yuanyu LianCollege of Pharmacy, Guilin Medical University, Guilin, China.
Zimeng LiCollege of Pharmacy, Guilin Medical University, Guilin, China.
Jie XuCollege of Pharmacy, Guilin Medical University, Guilin, China.
Mingli ZhongCollege of Pharmacy, Guilin Medical University, Guilin, China.
Jiani LiCollege of Pharmacy, Guilin Medical University, Guilin, China.
Riming WeiCollege of Pharmacy, Guilin Medical University, Guilin, China.
Jianghui DongCollege of Pharmacy, Guilin Medical University, Guilin, China.ORCID 0000-0001-9754-7683
Ling JinCollege of Pharmacy, Gansu University of Chinese Medicine, Lanzhou, China.
Guilin Medical University · CNGansu University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of this study was to alleviate liver disturbance by applying polysaccharides from Dicliptera chinensis (DCP) to act on the adenosine monophosphate-activated protein kinase/ nuclear factor erythroid 2-related factor 2 (AMPK/ Nrf2) oxidative stress pathway and the Toll-like receptor 4 (TLR-4)/ nuclear factor kappa-B (NF-κB) inflammatory pathway and to establish an in vivo liver disturbance model using male C57BL/6J and TLR-4 knockout (

Indexed as

Signal TransductionAcanthaceaeAMP-Activated Protein KinasesAnimalsHep G2 CellsHumansLipid MetabolismLiverMaleMice, Inbred C57BLModels, BiologicalNF-E2-Related Factor 2NF-kappa BOxidative StressPolysaccharidesToll-Like Receptor 4AMP-Activated Protein KinasesNF-E2-Related Factor 2NF-kappa BPolysaccharidesToll-Like Receptor 4AMPK/ Nrf2Dicliptera chinensis polysaccharidesliver disturbancesTLR-4/ NF-κB

Identifiers

PMID32337831
PMCPMC7294158
OpenAlexW3018624007

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.