Evidence map›Paper›PMID 32337773›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2020

Clinical importance of extended second field high-resolution HLA genotyping for kidney transplantation.

Aleksandar Senev, Marie-Paule Emonds, Vicky Van Sandt, Evelyne Lerut, Maarten Coemans, Ben Sprangers, Dirk Kuypers, Maarten Naesens

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06505200 (An Integrative Clinicopathological Decision Support System for Kidney Transplant Rejection), which is not on this map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
9.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06505200 active not recruitingnot on this map

An Integrative Clinicopathological Decision Support System for Kidney Transplant Rejection

TypeobservationalSponsorUniversitaire Ziekenhuizen KU LeuvenRan2004 to 2027Enrolled1,891ConditionsKidney Transplant Rejection, Kidney Transplantation, Kidney Transplant FailureArmsNo intervention
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 85 citations in OpenAlex.

  1. Trial
  2. Review
  3. Post-lung transplant surveillance in 2026: current practice, variability, and the need for standardization.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Review
  4. Article
  5. Imputed HLA typing as a practical approach to molecular mismatch risk stratification in kidney transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Article
  6. Anti-HLA antibodies in lung transplantation: diagnostic pitfalls and future directions.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  7. Review
  8. The Progress and Challenges of Implementing HLA Molecular Matching in Clinical Practice.Transplant international : official journal of the European Society for Organ Transplantation · 2025
    Review
  9. Frontiers in immunology · 2025
    Article
  10. Review
  11. Article
  12. Effects ofOpen life sciences · 2025
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Advancements in HLA Typing Techniques and Their Impact on Transplantation Medicine.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2024
    Review
  20. HLA-DR/DQ eplet mismatch predictsFrontiers in genetics · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Aleksandar SenevHistocompatibility and Immunogenetics Laboratory, Belgian Red Cross-Flanders, Mechelen, Belgium.ORCID 0000-0002-6196-4669
Marie-Paule EmondsHistocompatibility and Immunogenetics Laboratory, Belgian Red Cross-Flanders, Mechelen, Belgium.ORCID 0000-0002-2653-8656
Vicky Van SandtHistocompatibility and Immunogenetics Laboratory, Belgian Red Cross-Flanders, Mechelen, Belgium.ORCID 0000-0002-9748-4069
Evelyne LerutDepartment of Imaging & Pathology, University Hospitals Leuven, Leuven, Belgium.ORCID 0000-0003-3937-7190
Maarten CoemansDepartment of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.ORCID 0000-0001-8442-3673
Ben SprangersDepartment of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.ORCID 0000-0003-1314-9675
Dirk KuypersDepartment of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.ORCID 0000-0001-5546-9680
Maarten NaesensDepartment of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.ORCID 0000-0002-5625-0792
KU Leuven · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The need for extended second field high-resolution (2F-HR) HLA genotyping in kidney transplantation is debated. In a cohort of 1000 kidney transplants, we evaluated the impact of different HLA genotyping levels on the assignment of donor-specific anti-HLA antibodies (DSA) and investigated whether inference of 2F-HR genotypes from low-resolution (LR) genotypes could be used to correctly assign DSA. Based on LR genotypes, 224 pretransplant DSAs were present in 140 patients and absent in 860 patients (DSA

Indexed as

Graft RejectionHLA AntigensKidney TransplantationAdolescentAdultAgedAged, 80 and overFemaleGenotypeGraft SurvivalHistocompatibility TestingHumansIsoantibodiesMaleMiddle AgedRisk FactorsHLA AntigensIsoantibodiesbasic (laboratory) research/scienceclinical decision-makingclinical research/practicehistocompatibilitykidney transplantation/nephrologymajor histocompatibility complex (MHC)organ procurement and allocationpanel reactive antibody (PRA)rejection: antibody-mediated (ABMR)risk assessment/risk stratification

Identifiers

PMID32337773
PMCPMC7754319
OpenAlexW3018244286

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.