Evidence map›Paper›PMID 32337680›Full record

ArticleLasers in medical science2021

Intraoperative use of optical coherence tomography to differentiate normal and diseased thyroid and parathyroid tissues from lymph node and fat.

Marc Rubinstein, Allison C Hu, Phil-Sang Chung, Jason H Kim, Kathryn E Osann, Paul Schalch, William B Armstrong, Brian J F Wong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lasers in medical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Semiquantitative assessment ofFrontiers in endocrinology · 2022
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marc RubinsteinDepartement of Otolaryngology - Head and Neck Surgery, University of California Irvine, Orange, CA, USA.
Allison C HuDepartement of Otolaryngology - Head and Neck Surgery, University of California Irvine, Orange, CA, USA.
Phil-Sang ChungBeckman Laser Institute Korea, Dankook University, Cheonan, South Korea.
Jason H KimDepartement of Otolaryngology - Head and Neck Surgery, University of California Irvine, Orange, CA, USA.
Kathryn E OsannDepartment of Medicine, University of California Irvine, Orange, CA, USA.
Paul SchalchDepartement of Otolaryngology - Head and Neck Surgery, University of California Irvine, Orange, CA, USA.
William B ArmstrongDepartement of Otolaryngology - Head and Neck Surgery, University of California Irvine, Orange, CA, USA.
Brian J F WongDepartement of Otolaryngology - Head and Neck Surgery, University of California Irvine, Orange, CA, USA. bjwong@uci.edu.

Funding

ZOVIRAX CREAM TO TREAT HERPES LABIALIS IN ADOLESCENTSM01RR000827 · NCRR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHANG, R JEFFREY · 1985 to 2010
$74.3M
WOUND MIGRATION FORCE MONITORINGP41RR001192 · NCRR · UNIVERSITY OF CALIFORNIA-IRVINE · PI LYUBOVITSKY, JULIA · 1985 to 2011
$14.2M
Modeling the Pediatric Upper Airway using A-OCT and Computational Fluid DynamicsR01HL105215 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, ZHONGPING, ELGHOBASHI, SAID E. · 2010 to 2013
$3.7M
Diagnosis of Subglottic Stenosis and Edema in Neonates Using OCTR01HL103764 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI WONG, BRIAN · 2010 to 2014
$3.1M
Optical Biopsy Using MEMs TechnologyR01CA091717 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, ZHONGPING · 2002 to 2006
$2.9M
HIGH SPEED HIGH RESOLUTION PHASE RESOLVED OCT/ODTR01EB000293 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, ZHONGPING · 2002 to 2009
$1.9M
NonInvasive Optical Imaging of Vocal Cord MicrostructureR21DC006026 · NIDCD · UNIVERSITY OF CALIFORNIA IRVINE · PI WONG, BRIAN · 2003 to 2004
$301k
IN VIVO NMR STUDIES OF AGING IN CELLS AND ANIMALSZ01AG000113 · NIA · AGING · PI EICHHORN, G · 1985 to 1989
–
Air Force Office of Scientific Research F49620_00_1_0371Flight Attendant Medical Research Institute 32456NCI NIH HHS R01 CA091717NCRR NIH HHS M01 RR000827NCRR NIH HHS P41 RR001192NHLBI NIH HHS R01 HL103764NHLBI NIH HHS R01 HL105215NIBIB NIH HHS R01 EB000293NIDCD NIH HHS DC 006026NIDCD NIH HHS R21 DC006026State of California Tobacco Related Disease Research Program 12RT-0113
6 · The paper itself

Abstract

The purpose of this study is twofold: (1) to determine the feasibility of optical coherence tomography (OCT) to differentiate normal and diseased tissue of the neck region intraoperatively and (2) to evaluate how accurately a cohort of test subjects can identify various tissue types when shown a sample set of OCT images. In this in vivo, prospective, single institutional study, an OCT imaging system (Niris, Imalux, Cleveland, OH) was used to image parathyroid, thyroid, lymph node, and fat tissue in 76 patients during neck surgery. Biopsies were performed for comparison of OCT images with histology in select cases (n = 20). Finally, a group of either surgeons or scientists familiar with OCT (n = 17) were shown a sample of OCT images and asked to identify the tissue. A total of 437 OCT images were analyzed, and characteristic features of each tissue type were identified. OCT demonstrated distinct differences in structural architecture and signal intensity that allows differentiation between thyroid and parathyroid tissues, lymph nodes, and fat. OCT images were also compared with histology with good correlation. There was no difference in correctly identifying OCT-imaged tissue type between surgeons and scientists. This study is the first in vivo OCT imaging study to evaluate both normal and diseased tissues that may be encountered during neck surgery. OCT has the potential to become a valuable intraoperative tool to differentiate diseased and normal thyroid tissue intraoperatively to obtain an "optical biopsy" in real time without fixation, staining, or tissue resection.

Indexed as

Tomography, Optical CoherenceAdipose TissueAdolescentAdultAgedAged, 80 and overCohort StudiesFemaleHumansLymph NodesMaleMiddle AgedParathyroid GlandsProspective StudiesSurgeonsThyroid GlandHead and neckLymph nodeOCTOncologyOptical coherence tomographyOtolaryngologyParathyroidThyroid

Identifiers

PMID32337680
PMCPMC8897976

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.