ArticleJNCI cancer spectrum2020
Cancer in General Responders Participating in World Trade Center Health Programs, 2003-2013.
Article in JNCI cancer spectrum, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 50 citations in OpenAlex.
- Overcoming social determinants: World trade center health program monitoring use among the general responders.Preventive medicine reports · 2026Article
- Hidden in plain sight: a narrative review on environmental exposures and the fight against mesothelioma.Journal of thoracic disease · 2026Review
- Article
- The development of frailty trajectories in world trade center general responders and the association with World Trade Center Exposure.The Journal of frailty & aging · 2025Article
- Managing cancer following the World Trade Center disaster.Nature reviews. Cancer · 2024Article
- Colorectal cancer screening: results from the World Trade Center Health Registry cohort.Cancer causes & control : CCC · 2024Article
- Racial and ethnic disparities in mortality among World Trade Center Health Registry enrollees with post-9/11 cancer.Cancer medicine · 2024Article
- A pilot study to identify factors associated with frailty within the World Trade Center general responder cohort.American journal of industrial medicine · 2024Article
- Insights into the Molecular Mechanisms of Genetic Predisposition to Hematopoietic Malignancies: The Importance of Gene-Environment Interactions.Cancer discovery · 2024Article
- Lung cancer in patients who have never smoked - an emerging disease.Nature reviews. Clinical oncology · 2024Review
- Effects of trauma history on cancer-related screening, diagnosis, and treatment.The Lancet. Oncology · 2023Review
- TERT and BRAF V600E mutations in thyroid cancer of World Trade Center Responders.Carcinogenesis · 2023Article
- All-cause and cause-specific mortality in a cohort of WTC-exposed and non-WTC-exposed firefighters.Occupational and environmental medicine · 2023Article
- A 15-year follow-up study of mortality in a pooled cohort of World Trade Center rescue and recovery workers.Environmental research · 2023Article
- Mortality after the 9/11 terrorist attacks among world trade center health registry enrollees with cancer.Cancer medicine · 2023Article
- Characteristics of Cancers in Community Members Exposed to the World Trade Center Disaster at a Young Age.International journal of environmental research and public health · 2022Article
- Myeloma precursor disease (MGUS) among rescue and recovery workers exposed to the World Trade Center disaster.Blood cancer journal · 2022Observational
- Characterizing firefighter's exposure to over 130 SVOCs using silicone wristbands: A pilot study comparing on-duty and off-duty exposures.The Science of the total environment · 2022Article
- Lung cancer incidence among world trade center rescue and recovery workers.Cancer medicine · 2022Article
- Posttraumatic Stress Disorder Mediates the Association between Traumatic World Trade Center Dust Cloud Exposure and Ongoing Systemic Inflammation in Community Members.International journal of environmental research and public health · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFollowing the September 11, 2001, attacks on the World Trade Center (WTC), thousands of workers were exposed to an array of toxins known to cause adverse health effects, including cancer. This study evaluates cancer incidence in the WTC Health Program General Responder Cohort occurring within 12 years post exposure.
methodsThe study population consisted of 28 729 members of the General Responder Cohort enrolled from cohort inception, July 2002 to December 31, 2013. Standardized incidence ratios (SIRs) were calculated with cancer case inclusion and follow-up starting post September 11, 2001 (unrestricted) and, alternatively, to account for selection bias, with case inclusion and follow-up starting 6 months after enrollment in the WTC Health Program (restricted). Case ascertainment was based on linkage with six state cancer registries. Under the restricted criterion, hazard ratios were estimated using multivariable Cox proportional hazards models for all cancer sites combined and for prostate cancer.
resultsRestricted analyses identified 1072 cancers in 999 responders, with elevations in cancer incidence for all cancer sites combined (SIR = 1.09, 95% confidence interval [CI] = 1.02 to 1.16), prostate cancer (SIR = 1.25, 95% CI = 1.11 to 1.40), thyroid cancer (SIR = 2.19, 95% CI = 1.71 to 2.75), and leukemia (SIR = 1.41, 95% CI = 1.01 to 1.92). Cancer incidence was not associated with any WTC exposure index (composite or individual) for all cancer sites combined or for prostate cancer.
conclusionOur analyses show statistically significant elevations in cancer incidence for all cancer sites combined and for prostate and thyroid cancers and leukemia. Multivariable analyses show no association with magnitude or type of exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.