ArticleLaryngoscope investigative otolaryngology2020
The use of platelet-rich plasma in treatment of olfactory dysfunction: A pilot study.
Article in Laryngoscope investigative otolaryngology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Intranasal Injection of Platelet-rich Plasma Versus Saline for Treatment of Olfactory Dysfunction
"Platelet Rich Plasma for the Management of Post-Viral Olfactory Dysfunction.
Randomized Clinical Trial of Intranasal Injection of Platelet-Rich Plasma for Treatment of Parosmia
Carrier-Assisted Topical Application Versus Intranasal Injection of Autologous Platelet-Rich Plasma for Olfactory Dysfunction: A Randomized Controlled Trial
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Short-term efficacy of platelet-rich plasma in the treatment of persistent olfactory dysfunction: systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Pooled it
- Long-term Outcomes of PRP Injections for Post-viral Olfactory Loss: A Prospective Cohort Study.International forum of allergy & rhinology · 2025Trial
- The impact of submucosal PRP injection on wound healing after endoscopic sinus surgery: a randomized clinical trial.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Trial
- Use of platelet-rich plasma for COVID-19-related olfactory loss: a randomized controlled trial.International forum of allergy & rhinology · 2023Trial
- Effectiveness of platelet-rich plasma on post-COVID chronic olfactory dysfunction.Revista da Associacao Medica Brasileira (1992) · 2023Trial
- Efficacy of Platelet Rich Plasma Versus Placebo for Improvement in Olfactory Function in Adults With Olfactory Dysfunction: A Systematic Review and Meta-Analysis.Laryngoscope investigative otolaryngology · 2025Article
- Topical Anesthesia and Olfactory Capability: A Pilot Study.Laryngoscope investigative otolaryngology · 2025Article
- Effectiveness of platelet-rich plasma in long-lasting post-viral olfactory dysfunction: a case-series.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- Platelet-Rich Plasma (PRP) in the Treatment of Long COVID Olfactory Disorders: A Comprehensive Review.Biomedicines · 2024Review
- Pro-inflammatory markers associated with COVID-19-related persistent olfactory dysfunction.International forum of allergy & rhinology · 2024Article
- Efficacy of Platelet-Rich Plasma in the Treatment of Persistent Olfactory Impairment After COVID-19: A Systematic Review and Meta-Analysis.Journal of rhinology : official journal of the Korean Rhinologic Society · 2024Review
- Platelet-Rich Plasma for Patients with Olfactory Dysfunction: Myth or Reality? A Systematic Review.Journal of clinical medicine · 2024Review
- Delivery of Topical Drugs to the Olfactory Cleft.Journal of clinical medicine · 2023Review
- Platelet-rich plasma injection in the olfactory clefts of COVID-19 patients with long-term olfactory dysfunction.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023Article
- Olfactory Function and Olfactory Disorders.Laryngo- rhino- otologie · 2023Article
- Platelet-rich Plasma in Management of Anosmia (Single Versus Double Injections).Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- Post-viral olfactory loss and parosmia.BMJ medicine · 2023Review
- Post-traumatic olfactory dysfunction: a scoping review of assessment and rehabilitation approaches.Frontiers in neurology · 2023Article
- COVID and smell loss: answers begin to emerge.Nature · 2022Article
- International consensus statement on allergy and rhinology: Olfaction.International forum of allergy & rhinology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOlfactory dysfunction is a prevalent problem with a significant impact on quality of life and increased mortality. Limited effective therapies exist. Platelet-rich plasma (PRP) is an autologous biologic product with anti-inflammatory and neuroprotective effects. This novel pilot study evaluated the role of PRP on olfactory neuroregeneration in patients with hyposmia.
methodsSeven patients who had olfactory loss greater than 6 months in duration, no evidence of sinonasal inflammatory disease, and no improvement with olfactory training and budesonide topical rinses were enrolled in this preliminary study. Patients received a single intranasal injection of PRP into the mucosa of the olfactory cleft. The Sniffin' Sticks olfactory test consisting of threshold, discrimination, and identification measurements (TDI) was administered at the beginning of the study and at 1 and 3 months.
resultsAll patients reported a subjective improvement of their smell shortly after injection but then stabilized. At 3-month post-treatment, two patients with functional anosmia (TDI < 16) did not improve significantly. Five patients with hyposmia (TDI > 16 but <30) showed an improvement with 60% achieving normosmia (TDI > 30) at 3-month follow-up. On average, patients with baseline TDI > 16 improved by 5.85 points with the most significant improvement in the threshold subcomponent. There were no adverse outcomes from intranasal PRP injections.
conclusionPRP appears safe for use in the treatment of olfactory loss, and preliminary data suggest possible efficacy, especially for those with moderate yet persistent loss. Further studies will help determine optimal frequency and duration of use. LEVEL OF EVIDENCE 2B:
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.