ArticleBioMed research international2020
Hepatoprotective Effect of Oleuropein-Rich Extract from Olive Leaves against Cadmium-Induced Toxicity in Mice.
Article in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- Epigenetic Regulations by Olive Bioactives: Targeting HDAC for Disease Prevention and Therapy.Current nutrition reports · 2026Review
- Targeting Diabetic Complications through Oleuropein-Mediated Enzyme Modulation: A Chemical Biology Study in the Human-Relevant ModelACS omega · 2025Article
- Effects of a green method olive leaf extract on the metabolic disorders and the pancreatic immunohistopathology in diabetic Wistar rats.3 Biotech · 2025Article
- Investigation of Cannabidiol's Protective Effects on Cadmium-Induced Toxicity in Mice.Basic & clinical pharmacology & toxicology · 2025Article
- Mechanisms of Metal-Induced Hepatic Inflammation.Current environmental health reports · 2024Review
- Oleuropein, a Component of Extra Virgin Olive Oil, Improves Liver Steatosis and Lobular Inflammation by Lipopolysaccharides-TLR4 Axis Downregulation.International journal of molecular sciences · 2024Article
- Emerging insights into the impacts of heavy metals exposure on health, reproductive and productive performance of livestock.Frontiers in pharmacology · 2024Review
- Ameliorative Effects of Oyster Protein Hydrolysates on Cadmium-Induced Hepatic Injury in Mice.Marine drugs · 2022Article
- Optimizing the Extraction Conditions of Hydroxytyrosol from Olive Leaves Using a Modified Spherical Activated Carbon: A New Experimental Design.BioMed research international · 2022Article
- Article
- Olive leaf extract supplementation improves the vascular and metabolic alterations associated with aging in Wistar rats.Scientific reports · 2021Article
- Nutraceutical Properties of Polyphenols against Liver Diseases.Nutrients · 2020Review
- Potential Hepatoprotective Activity of Super Critical Carbon Dioxide Olive Leaf Extracts against CClFoods (Basel, Switzerland) · 2020Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cadmium (Cd) is a harmful pollutant which mainly affects the liver and kidney. In this work, we investigated the hepatoprotective effects of olive leaf extract based on oleuropein against hepatic cadmium toxicity in mice. Three groups of animals were used: the first one served as the control (C); the second one received intraperitoneal injection of cadmium 2 mg/kg b.w. (CD), administered five times during two weeks; and the third group received the same doses of Cd and simultaneously 16 mg/kg b.w. of oleuropein. Results showed that Cd induced a significant increase in liver injury biomarkers coupled with enhanced lipid peroxidation (MDA) and significant depletion of antioxidants (CAT and SOD). Histological and immunohistochemical analysis confirmed these findings. In fact, we observed a severe central lobular apoptosis and inflammation around central veins. Cotreatment with oleuropein significantly reduced the oxidative damage induced by cadmium. Our findings suggest that oleuropein could be used in the prevention of Cd hepatotoxicity.
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