Evidence map›Paper›PMID 32337181›Full record

ArticleJournal of biomedical physics & engineering2020

Changes in the Radiation Toxicity of Human Lymphoblastic T-cell Line (Jurkat) by a Common Pesticide: Diazinon.

Ghasemi Sh, Shabestani Monfared A, Zabihi E, Khoshbin Khoshnazar A, Asadi J, Abedian Z, Borzoueisileh S

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Article in Journal of biomedical physics & engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ghasemi ShMSc, Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
Shabestani Monfared APhD, Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Zabihi EPhD, Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Khoshbin Khoshnazar APhD, Faculty of Medi-cine, Golestan University of Medical Sciences, Gorgan, Iran.
Asadi JPhD, Biochemistry and Metabolic Disorders Re-search Center, Golestan University of Medical Sciences, Gorgan, Iran.
Abedian ZPhD Candidate, Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medi-cal Sciences, Babol, Iran.
Borzoueisileh SPhD Candidate, Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medi-cal Sciences, Babol, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiazinon is one of the most common pesticides in the world playing a similar role to radiation and it could cause DNA breaks and genetic effects.

objectiveIn this study, radiosensitivity of a lymphoblastic cell line pretreated by Diazinon was investigated. MATERIAL AND

methodsIn this case-control study, the human lymphoblastic T-cell line was divided into 6 groups based on receiving radiation or/and Diazinon. After that, the DNA damage, in all of the groups, were counted by cytokinesis-block micronuclei assay using different indices.

resultsThe mean frequency of micronuclei, nuclear bridges and nuclear buds in cell groups exposed by both Diazinon and radiation were remarkably higher than the other groups which just received radiation or Diazinon alone. The interaction between radiation and Diazinon treatment was statistically significant for NBUDS index.

conclusionThe results indicated that the Diazinon contamination could affect the radiosensitivity index of cancerous cells while further molecular and in-vivo studies are needed to investigate genetic and toxic effects of Diazinon on DNA and its repair system.

Indexed as

DiazinonJurkat CellsPesticidesRadiation ToleranceRadiotherapy

Identifiers

PMID32337181
PMCPMC7166222

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