ArticleLight, science & applications2020
Spatial heterogeneity of oxygenation and haemodynamics in breast cancer resolved in vivo by conical multispectral optoacoustic mesoscopy.
Article in Light, science & applications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed.
- Harnessing Rare-Earth Materials as Exogenous Contrast Agents for Enhanced Photoacoustic Imaging.Chemical & biomedical imaging · 2026Review
- Dual SwinUNet architecture for enhanced photoacoustic imaging: a contrastive learning approach in image and sinogram domains.Journal of biomedical optics · 2026Article
- All-fiber photoacoustic endomicroscopy reveals layer-specific angiogenesis-oxygenation uncoupling in experimental colitis.Science advances · 2026Article
- Review
- Integrative QSP Modeling of Cancer Stem Cells in Triple-Negative Breast Cancer: Impacts on Tumor Immunity and Response to Immune Checkpoint Inhibitors.CPT: pharmacometrics & systems pharmacology · 2026Article
- Assessment of the angiogenic potential of xenografted tumors by biomedical imaging techniques.Biomedical optics express · 2026Article
- Photoacoustic Microscopy for Multiscale Biological System Visualization and Clinical Translation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- A histone acetylation score for prognostic stratification and immunogenomic profiling in esophageal cancer.Discover oncology · 2025Article
- Revolutionizing HER-2 assessment: multidimensional radiomics in breast cancer diagnosis.BMC cancer · 2025Article
- Enhanced dual-mode imaging: Superior photoacoustic and ultrasound endoscopy in live pigs using a transparent ultrasound transducer.Science advances · 2024Article
- 3D Multiparametric Photoacoustic Computed Tomography of Primary and Metastatic Tumors in Living Mice.ACS nano · 2024Article
- Photoacoustic Tomography with Temporal Encoding Reconstruction (PATTERN) for cross-modal individual analysis of the whole brain.Nature communications · 2024Article
- Photoacoustic imaging on its way toward clinical utility: a tutorial review focusing on practical application in medicine.Journal of biomedical optics · 2023Review
- Niche preclinical and clinical applications of photoacoustic imaging with endogenous contrast.Photoacoustics · 2023Review
- Photoacoustic spectrum analysis for spherical target size and optical property determination: A feasibility study.Photoacoustics · 2023Article
- Panoramic volumetric clinical handheld photoacoustic and ultrasound imaging.Photoacoustics · 2023Article
- In vivo co-registered hybrid-contrast imaging by successive photoacoustic tomography and magnetic resonance imaging.Photoacoustics · 2023Article
- A high-precision multi-dimensional microspectroscopic technique for morphological and properties analysis of cancer cell.Light, science & applications · 2023Article
- Mapping Spatiotemporal Heterogeneity in Tumor Profiles by Integrating High-Throughput Imaging and Omics Analysis.ACS omega · 2023Review
- Assessment of spatial transcriptomics for oncology discovery.Cell reports methods · 2022Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The characteristics of tumour development and metastasis relate not only to genomic heterogeneity but also to spatial heterogeneity, associated with variations in the intratumoural arrangement of cell populations, vascular morphology and oxygen and nutrient supply. While optical (photonic) microscopy is commonly employed to visualize the tumour microenvironment, it assesses only a few hundred cubic microns of tissue. Therefore, it is not suitable for investigating biological processes at the level of the entire tumour, which can be at least four orders of magnitude larger. In this study, we aimed to extend optical visualization and resolve spatial heterogeneity throughout the entire tumour volume. We developed an optoacoustic (photoacoustic) mesoscope adapted to solid tumour imaging and, in a pilot study, offer the first insights into cancer optical contrast heterogeneity in vivo at an unprecedented resolution of <50 μm throughout the entire tumour mass. Using spectral methods, we resolve unknown patterns of oxygenation, vasculature and perfusion in three types of breast cancer and showcase different levels of structural and functional organization. To our knowledge, these results are the most detailed insights of optical signatures reported throughout entire tumours in vivo, and they position optoacoustic mesoscopy as a unique investigational tool linking microscopic and macroscopic observations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.