ArticleGlobal ecology and biogeography : a journal of macroecology2020
Distinct spread of DNA and RNA viruses among mammals amid prominent role of domestic species.
Article in Global ecology and biogeography : a journal of macroecology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
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- Zoon0PredV: Potential Virus Species Crossover Prediction Using Convolutional Neural Networks and Viral Protein Sequence Patterns.Bioinformatics and biology insights · 2026Article
- Unveiling Novel Viral Diversity, Biogeography, and Host Networks in Wildlife Through High-Throughput Sequencing Data Mining.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Small mammals in a biodiversity hotspot harbor viruses of emergence risk.National science review · 2025Article
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- A One Health framework for exploring zoonotic interactions demonstrated through a case study.Nature communications · 2024Article
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- A species-level trait dataset of bats in Europe and beyond.Scientific data · 2023Article
- Ancient pathogens provide a window into health and well-being.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Adaptive Evolution of the OAS Gene Family Provides New Insights into the Antiviral Ability of Laurasiatherian Mammals.Animals : an open access journal from MDPI · 2023Article
- Enveloped viruses show increased propensity to cross-species transmission and zoonosis.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Managing host-parasite interactions in humans and wildlife in times of global change.Parasitology research · 2022Review
- Viral spillover risk increases with climate change in High Arctic lake sediments.Proceedings. Biological sciences · 2022Article
- Screening of cell-virus, cell-cell, gene-gene crosstalk among animal kingdom at single cell resolution.Clinical and translational medicine · 2022Article
- Climate Anomalies and Spillover of Bat-Borne Viral Diseases in the Asia-Pacific Region and the Arabian Peninsula.Viruses · 2022Article
- Cellular and immunological mechanisms influence host-adapted phenotypes in a vector-borne microparasite.Proceedings. Biological sciences · 2022Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
aimEmerging infectious diseases arising from pathogen spillover from mammals to humans constitute a substantial health threat. Tracing virus origin and predicting the most likely host species for future spillover events are major objectives in One Health disciplines.We assessed patterns of virus sharing among a large diversity of mammals, including humans and domestic species. LOCATION: Global. TIME PERIOD: Current. MAJOR TAXA STUDIED: Mammals and associated viruses.
methodsWe used network centrality analysis and trait-based Bayesian hierarchical models to explore patterns of virus sharing among mammals. We analysed a global database that compiled the associations between 1,785 virus species and 725 mammalian host species as sourced from automatic screening of meta-data accompanying published nucleotide sequences between 1950 and 2019.
resultsWe show that based on current evidence, domesticated mammals hold the most central positions in networks of known mammal-virus associations. Among entire host-virus networks, Carnivora and Chiroptera hold central positions for mainly sharing RNA viruses, whereas ungulates hold central positions for sharing both RNA and DNA viruses with other host species. We revealed strong evidence that DNA viruses were phylogenetically more host specific than RNA viruses. RNA viruses exhibited low functional host specificity despite an overall tendency to infect phylogenetically related species, signifying high potential to shift across hosts with different ecological niches. The frequencies of sharing viruses among hosts and the proportion of zoonotic viruses in hosts were larger for RNA than for DNA viruses. MAIN
conclusionsAcknowledging the role of domestic species in addition to host and virus traits in patterns of virus sharing is necessary to improve our understanding of virus spread and spillover in times of global change. Understanding multi-host virus-sharing pathways adds focus to curtail disease spread.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.