ArticleBritish journal of anaesthesia2020
Dynamic changes in rhythmic and arrhythmic neural signatures in the subthalamic nucleus induced by anaesthesia and tracheal intubation.
Article in British journal of anaesthesia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06400901 (Electrophysiology Based Brain Network Study on Deep Brain Nuclei LFP and Cortical EEG During the Recovery From General Anesthesia), which is not on this map. Cited by 11 papers.
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Electrophysiology Based Brain Network Study on Deep Brain Nuclei LFP and Cortical EEG During the Recovery From General Anesthesia
Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Advances in local field potential research in prolonged disorders of consciousness: a narrative review.Chinese neurosurgical journal · 2026Review
- Subthalamic CaMKIIα-expressing neurons facilitate recovery from propofol anesthesia via the STN-ventral pallidum pathway.Cell biology and toxicology · 2026Article
- Remifentanil-esketamine-based General Anesthesia Strategy for Microelectrode-guided Deep-brain Stimulation for Parkinson Disease.Anesthesiology · 2026Article
- Electroencephalogram spectral power changes signalling the loss of volitional control induced by propofol: a secondary analysis of an observational study in spinal surgery patients.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2026Observational
- [Current progress on characteristics of intracranial electrophysiology related to prolonged disorders of consciousness].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024Review
- Aperiodic components of local field potentials reflect inherent differences between cortical and subcortical activity.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Subthalamic nucleus dynamics track microlesion effect in Parkinson's disease.Frontiers in cell and developmental biology · 2024Article
- Anesthetic spindles serve as EEG markers of the depth variations in anesthesia induced by multifarious general anesthetics in mouse experiments.Frontiers in pharmacology · 2024Article
- Article
- Deep brain stimulation for movement disorder treatment: exploring frequency-dependent efficacy in a computational network model.Biological cybernetics · 2022Article
- Article
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Authors and funding
15 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundSubcortical structures, including the basal ganglia, have been proposed to be crucial for arousal, consciousness, and behavioural responsiveness. How the basal ganglia contribute to the loss and recovery of consciousness during anaesthesia has, however, not yet been well characterised.
methodsTwelve patients with advanced Parkinson's disease, who were undergoing deep brain stimulation (DBS) electrode implantation in the subthalamic nucleus (STN), were included in this study. Local field potentials (LFPs) were recorded from the DBS electrodes and EEG was recorded from the scalp during induction of general anaesthesia (with propofol and sufentanil) and during tracheal intubation. Neural signatures of loss of consciousness and of the expected arousal during intubation were sought in the STN and EEG recordings.
resultsPropofol-sufentanil anaesthesia resulted in power increases in delta, theta, and alpha frequencies, and broadband power decreases in higher frequencies in both STN and frontal cortical areas. This was accompanied by increased STN-frontal cortical coherence only in the alpha frequency band (119 [68]%; P=0.0049). We observed temporal activity changes in STN after tracheal intubation, including power increases in high-beta (22-40 Hz) frequency (98 [123]%; P=0.0064) and changes in the power-law exponent in the power spectra at lower frequencies (2-80 Hz), which were not observed in the frontal cortex. During anaesthesia, the dynamic changes in the high-gamma power in STN LFPs correlated with the power-law exponent in the power spectra at lower frequencies (2-80 Hz).
conclusionsApart from similar activity changes in both STN and cortex associated with anaesthesia-induced unresponsiveness, we observed specific neuronal activity changes in the STN in response to the anaesthesia and tracheal intubation. We also show that the power-law exponent in the power spectra in the STN was modulated by tracheal intubation in anaesthesia. Our results support the hypothesis that subcortical nuclei may play an important role in the loss and return of responsiveness.
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