Trial reportBMC medical research methodology2020
Study design factors influencing patients' willingness to participate in clinical research: a randomised vignette-based study.
Trial report in BMC medical research methodology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05654103 (Randomized Controlled Trial Comparing endoAVF Versus surgAVF), which is not on this map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Controlled Trial Comparing endoAVF Versus surgAVF
Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Trial
- Weighing Open Science Against Research Participation Burden in Informed Consent: A Randomized Pilot Study.Journal of empirical research on human research ethics : JERHRE · 2025Trial
- Feasibility, fidelity and initial effects of an app-based service for short-term antibiotic therapy: A pilot study in a primary care setting.Exploratory research in clinical and social pharmacy · 2026Article
- Attitudes and Willingness to Participate in Drug Clinical Trials Among Patients With Cancer: Multistage Qualitative Study.Journal of medical Internet research · 2026Article
- Vietnamese University Students' Perceptions and Attitudes Toward Participation in Clinical Research: Mixed Methods Study.Journal of participatory medicine · 2026Article
- Methodology and predictive accuracy of the prospective preference assessment for randomized trial enrollment: A literature review.Osteoarthritis and cartilage open · 2025Review
- Patients and Communities Shape Regional Health Research Priorities: A Participatory Study from South Tyrol, Italy.Healthcare (Basel, Switzerland) · 2025Article
- Improving Recruitment Into Research Studies via Electronically Collected Patient-Entered Data: Mixed Methods Study.Journal of medical Internet research · 2025Article
- Characteristics of clinical trials associated with appeal and return on investment to participants: a review and framework.The oncologist · 2025Review
- Sex Differences in the Participation in Secondary Prevention Stroke Studies.Journal of the American Heart Association · 2025Article
- Prospective Preference Assessment of a Pharmacological Clinical Trial to Alter the Progression of Posttraumatic Osteoarthritis After ACL Reconstruction.Orthopaedic journal of sports medicine · 2025Article
- Applying Nociplastic Pain Criteria in Chronic Musculoskeletal Conditions: A Vignette Study.Journal of clinical medicine · 2025Article
- "I'm tired of seeing my friends die": Barriers and facilitators to participating in clinical trials among rural people who use drugs in the United States.The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association · 2025Article
- Alter egos alter engagement: perspective-taking can improve disclosure quantity and depth to AI chatbots in promoting mental wellbeing.Frontiers in digital health · 2025Article
- Impact of gender on the willingness to participate in clinical trials and undergo related procedures in individuals from an Alzheimer's prevention research cohort.Alzheimer's research & therapy · 2024Article
- More than Just a Number: Perspectives from Black Male Participants on Community-Based Interventions and Clinical Trials to Address Cardiovascular Health Disparities.International journal of environmental research and public health · 2024Article
- Clinical Research: A Review of Study Designs, Hypotheses, Errors, Sampling Types, Ethics, and Informed Consent.Cureus · 2023Review
- How do study design features and participant characteristics influence willingness to participate in clinical trials? Results from a choice experiment.BMC medical research methodology · 2022Article
- Article
- Translation and validation of the greek version of a questionnaire measuring patient views on participation in clinical trials.BMC health services research · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHigh patient participation in clinical research reduces selection bias and ensures the generalizability of study findings. We explored study-related factors that may influence patients' willingness to participate in research.
methodsWe submitted by mail two vignettes that described clinical research studies - a drug trial and a diagnostic study - to patients recently discharged from hospital and assessed their willingness to participate. We used a factorial design to randomly allocate three study attributes per vignette: in the drug trial, presumed superiority of new drug versus equipoise, public versus industry funding, and random versus non-random treatment allocation; in the diagnostic study, common versus rare disease, genetic versus protein analysis, and automatic reporting of results versus reporting on request.
resultsOf 2600 patients contacted, 1140 (44%) participated. Globally, willingness to participate in a drug trial was lower than in a diagnostic study (44.8% vs. 76.2%; P < 0.001). In the drug trial, participation was significantly higher when the new drug was presented as presumably better than the old (vs. equipoise) and when the study was funded by public sources (vs. industry), but was not affected by the allocation method. None of the factors tested in the diagnostic study was associated with participation.
conclusionsPatients were more likely to participate in a hypothetical observational diagnostic study than in a hypothetical drug trial. Participation in the trial was lower when clinical equipoise was expressed and when the trial was funded by industry. These results suggest that some features of study design can influence participation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.