SynthesisNeurosurgical review2021
A systematic review of surgical treatments of idiopathic intracranial hypertension (IIH).
Synthesis in Neurosurgical review, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05647837 (Value of Cerebrospinal Fluid), which is not on this map. Cited by 63 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Value of Cerebrospinal Fluid (CSF) Biomarkers in Patients of Idiopathic Intracranial Hypertension (IIH) as an Indicative of Visual Affection and Treatment Modalities
Who cites it
63 citing papers in PubMed, 4 syntheses or guidelines pooled it, 141 citations in OpenAlex.
- Therapeutic role of venous sinus stenting in pediatric IIH: evidence review for clinical practice.Acta neurochirurgica · 2025Pooled it
- The Effect of Metabolic and Bariatric Surgery on Patients with Idiopathic Intracranial Hypertension; A Systematic Review and Meta-analysis.Obesity surgery · 2025Pooled it
- Effectiveness of optic nerve sheath fenestration in preserving vision in idiopathic intracranial hypertension: an updated meta-analysis and systematic review.Acta neurochirurgica · 2024Pooled it
- A systematic review of surgical and interventional radiology procedures for pediatric idiopathic intracranial hypertension.Frontiers in pediatrics · 2024Pooled it
- Optic nerve sheath fenestration in leukemic patients having increased intracranial pressure: a prospective clinical trial.International ophthalmology · 2021Trial
- Migratory Venous Sinus Stenosis After Stenting for Idiopathic Intracranial Hypertension: a Single-Center Case Series.Clinical neuroradiology · 2026Article
- Article
- Transverse venous sinus stenting versus cerebrospinal fluid shunting in idiopathic intracranial hypertension: a multi-institutional and multinational database study.Journal of neurointerventional surgery · 2026Article
- Surgical Interventions in Idiopathic Intracranial Hypertension-A Comprehensive Multi-Center Study of Outcome and the Role of Treatment Indication.European journal of neurology · 2026Observational
- Ventriculoperitoneal shunt versus transverse sinus stenting in idiopathic intracranial hypertension: A systematic review and meta-analysis.Brain & spine · 2026Review
- The Impact of Venous Stenting on Symptoms and Quality of Life in Patients with Idiopathic Intracranial Hypertension and Spontaneous Cerebrospinal Fluid Leak.Journal of neurological surgery. Part B, Skull base · 2025Article
- Prediction of Poor Visual Outcomes at Idiopathic Intracranial Hypertension Diagnosis Using a Supervised Machine Learning Algorithm.Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society · 2025Article
- Surgical outcomes of optic nerve sheath fenestration in pediatric pseudotumor cerebri syndrome.BMC ophthalmology · 2025Article
- Interpretable Multiomics Models for Predicting Surgical Interventions and Blood Transfusion Requirements in Traumatic Brain Injury.NPJ digital medicine · 2025Article
- Idiopathic Intracranial Hypertension Animal Models and Venous Sinus Stenting: Status of Disease and Device-Focused Evidence.Brain sciences · 2025Review
- Fulminant idiopathic intracranial hypertension mimicking Chiari I malformation in a pediatric patient: diagnostic value of MRI and promising outcomes with venous sinus stenting.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Review
- Venous sinus stenting versus ventriculoperitoneal shunting: Comparing perioperative costs for idiopathic intracranial hypertension.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- The effect of glucagon-like peptide-1 agonists on ocular parameters in idiopathic intracranial hypertension patients: a retrospective study.Eye (London, England) · 2025Article
- Repeat venous sinus stenting for management of recurrent sinus stenosis related treatment failure of idiopathic intracranial hypertension: A case series.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Liraglutide for idiopathic intracranial hypertension: a real-world propensity score-matched study.Annals of clinical and translational neurology · 2025Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Idiopathic intracranial hypertension denotes raised intracranial pressure in the absence of an identifiable cause and presents with symptoms relating to elevated ICP, namely headaches and visual deterioration. Treatment of IIH aims at reducing intracranial pressure, relieving headache and salvaging patients' vision. Surgical interventions are recommended for medically refractory IIH and include CSF diversion techniques, optic nerve sheath fenestration, bariatric surgery and venous sinus stenting. Prospective studies on the surgical options for IIH are scant and no evidence-based guidelines for the surgical management of medically refractory IIH have been established. A search in Cochrane Library, MEDLINE and EMBASE from 1 January 1985 to 19 April 2019 for controlled or observational studies on the surgical treatment of IIH (defined in accordance with the modified Dandy or the modified Friedman criteria) in adults yielded 109 admissible studies. VSS improved papilledema, visual fields and headaches in 87.1%, 72.7% and 72.1% of the patients respectively, with a 2.3% severe complication rate and 11.3% failure rate. CSF diversion techniques diminished papilledema, visual field deterioration and headaches in 78.9%, 66.8% and 69.8% of the cases and are associated with a 9.4 severe complication rate and a 43.4% failure rate. ONSF ameliorated papilledema, visual field defects and headaches in 90.5, 65.2% and 49.3% of patients. Severe complication rate was 2.2% and failure rate was 9.4%. This is currently the largest systematic review for the available operative modalities for IIH. VSS provided the best results in headache resolution and visual outcomes, with low failure rates and a very favourable complication profile. In light of this, VSS ought to be regarded as the first-line surgical modality for the treatment of medically refractory IIH.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.