Evidence map›Paper›PMID 32335802›Full record

ReviewFrontiers of medicine2020

Biological properties and clinical applications of berberine.

Danyang Song, Jianyu Hao, Daiming Fan

Abstract readReview
PubMed Publisher
In one paragraph

Review in Frontiers of medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 259 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
259citing papers in PubMed, 7 pooled it
27.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

259 citing papers in PubMed, 7 syntheses or guidelines pooled it, 454 citations in OpenAlex.

  1. Pooled it
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  5. Berberine and health outcomes: an overview of systematic reviews.BMC complementary medicine and therapies · 2025
    Pooled it
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  8. Trial
  9. Article
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  11. Article
  12. Review
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  15. Article
  16. Berberine Poisoning with Polymorphic Ventricular Tachycardia: A Case Report.Clinical practice and cases in emergency medicine · 2026
    Article
  17. Review
  18. Article
  19. Article
  20. Article

199 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Danyang SongDepartment of Gastroenterology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.
Jianyu HaoDepartment of Gastroenterology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China. haojianyu@medmail.com.cn.
Daiming FanDepartment of Gastroenterology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China. daimingfan@fmmu.edu.cn.
Beijing Chao-Yang Hospital · CNCapital Medical University · CNNational Clinical Research Center for Digestive Diseases · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Berberine, an isoquinoline alkaloid isolated from the Chinese herb Coptis chinensis and other Berberis plants, has a wide range of pharmacological properties. Berberine can be used to treat many diseases, such as cancer and digestive, metabolic, cardiovascular, and neurological diseases. Berberine has protective capacities in digestive diseases. It can inhibit toxins and bacteria, including Helicobacter pylori, protect the intestinal epithelial barrier from injury, and ameliorate liver injury. Berberine also inhibits the proliferation of various types of cancer cells and impedes invasion and metastasis. Recent evidence has confirmed that berberine improves the efficacy and safety of chemoradiotherapies. In addition, berberine regulates glycometabolism and lipid metabolism, improves energy expenditure, reduces body weight, and alleviates nonalcoholic fatty liver disease. Berberine also improves cardiovascular hemodynamics, suppresses ischemic arrhythmias, attenuates the development of atherosclerosis, and reduces hypertension. Berberine shows potent neuroprotective effects, including antioxidative, antiapoptotic, and anti-ischemic. Furthermore, berberine exerts protective effects against other diseases. The mechanisms of its functions have been extensively explored, but much remains to be clarified. This article summarizes the main pharmacological actions of berberine and its mechanisms in cancer and digestive, metabolic, cardiovascular, and neurological diseases.

Indexed as

BerberineBerberisCoptisLipid MetabolismBerberineberberineclinical applicationsCoptis chinensismechanismpharmacological properties

Identifiers

PMID32335802
OpenAlexW3017396243

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.