Evidence map›Paper›PMID 32335793›Full record

ArticleVirus genes2020

Crimean-Congo hemorrhagic fever virus infection triggers the upregulation of the Wnt signaling pathway inhibitor genes.

Henrietta Papp, Safia Zeghbib, Fanni Földes, Krisztina Banfai, Mónika Madai, Gábor Kemenesi, Péter Urbán, Krisztián Kvell, Ferenc Jakab

Abstract read
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In one paragraph

Article in Virus genes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.0field-weighted citation impact, top 62% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Henrietta PappVirological Research Group, BSL-4 Laboratory, Szentágothai Research Centre, University of Pécs, Pécs, Ifjúság útja 20, 7624, Hungary.ORCID https://orcid.org/0000-0003-3887-5657
Safia ZeghbibVirological Research Group, BSL-4 Laboratory, Szentágothai Research Centre, University of Pécs, Pécs, Ifjúság útja 20, 7624, Hungary.ORCID https://orcid.org/0000-0001-9603-7489
Fanni FöldesVirological Research Group, BSL-4 Laboratory, Szentágothai Research Centre, University of Pécs, Pécs, Ifjúság útja 20, 7624, Hungary.
Krisztina BanfaiWnt Signaling Research Group, Szentágothai Research Centre, University of Pécs, Pécs, Hungary.
Mónika MadaiVirological Research Group, BSL-4 Laboratory, Szentágothai Research Centre, University of Pécs, Pécs, Ifjúság útja 20, 7624, Hungary.
Gábor KemenesiVirological Research Group, BSL-4 Laboratory, Szentágothai Research Centre, University of Pécs, Pécs, Ifjúság útja 20, 7624, Hungary.ORCID https://orcid.org/0000-0001-9775-3065
Péter UrbánFaculty of Sciences, Institute of Biology, University of Pécs, Pécs, Hungary.
Krisztián KvellWnt Signaling Research Group, Szentágothai Research Centre, University of Pécs, Pécs, Hungary.
Ferenc JakabVirological Research Group, BSL-4 Laboratory, Szentágothai Research Centre, University of Pécs, Pécs, Ifjúság útja 20, 7624, Hungary. jakab.ferenc@pte.hu.ORCID https://orcid.org/0000-0002-3913-0430
University of Pecs · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Crimean-Congo hemorrhagic fever virus (CCHFV) is a highly pathogenic agent. Thus far, vaccines and specific antiviral therapies are not available against the threat of infection. Our knowledge regarding its pathogenesis is indeed limited, and thus, developing effective antiviral therapies is hampered. Several studies have demonstrated that the CCHFV infection has an impact on numerous signal transduction pathways. In parallel, the Wnt signaling pathway components are responsible for different important biological processes including cell fate determination, cell migration and cell polarity. Moreover, its implication among several virus infections has been proven, yet little is known in reference to which components of the Wnt pathway are being activated/inhibited as a response to the infection. Our aim was to elicit the influence of the CCHFV infection on adenocarcinomic human alveolar basal epithelial cells in vitro regarding the Wnt signaling pathway-related genes. Gene-expression changes of 92 Wnt-associated genes were examined 48 h post-infection. Furthermore, β-catenin levels were compared in the infected and uninfected cells. Significant changes were observed in the case of 13 genes. The majority of the upregulated genes are associated with the inhibition of the Wnt/β-catenin signaling. Additionally, infected cells expressed less β-catenin. Our findings suggest that CCHFV blocks the Wnt/β-catenin pathway. Our study corroborates the link between CCHFV infection and the Wnt signaling pathways. In addition, it broadens our knowledge in the CCHFV pathomechanism.

Indexed as

AnimalsCell Line, TumorGene Expression Regulation, ViralHemorrhagic Fever, CrimeanHemorrhagic Fever Virus, Crimean-CongoHumansVirus ReplicationWnt Signaling PathwayA549Gene expressionHemorrhagic fever virusHighly pathogenicImmunofluorescenceWnt/ß-catenin signaling pathway

Identifiers

PMID32335793
OpenAlexW3018672594

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.