ArticleArchives of virology2020
Isolation and identification of two new strains of mammalian orthoreovirus from Chinese tree shrews.
Article in Archives of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Genomic Characteristics and Pathogenicity of Novel Reassortant Mammalian Orthoreoviruses From Sheep, China.Transboundary and emerging diseases · 2025Article
- Identification of multiple inter- and intra-genotype reassortment mammalian orthoreoviruses from Japanese black cattle in a beef cattle farm.Scientific reports · 2024Article
- Identification of novel mammalian viruses in tree shrews (Zoological research · 2024Article
- Isolation and genetic characterization of a mammalian orthoreovirus from Vespertilio sinensis in Japan.Archives of virology · 2023Article
- Intertypic reassortment of mammalian orthoreovirus identified in wastewater in Japan.Scientific reports · 2021Article
- Isolation and characterization of mammalian orthoreovirus type 3 from a fecal sample from a wild boar in Japan.Archives of virology · 2021Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Chinese tree shrews have been used extensively in studies of different types of cancer and for the modeling of viral infections. In the present study, we report the isolation and characterization of two strains of mammalian orthoreovirus (MRV), MRV1/TS/2011 and MRV3/TS/2012, which were isolated from the feces of tree shrews in Yunnan, China. These two strains of MRV were isolated and cultured in both primary tree shrew intestinal epithelial cells (pTIECs) and primary tree shrew alveolar epithelial cells (pTAECs). A neutralization test using immunofluorescence was employed to determine the subtype of each isolate. Viral RNA was extracted and analyzed by polyacrylamide gel electrophoresis (PAGE), and the sequence was determined by next-generation sequencing for construction of a phylogenetic tree and analysis of gene polymorphism. Electron microscopy examination revealed the presence of virus particles with the typical morphological characteristics of MRV. Serotype analysis showed that strain MRV1/TS/2011 was of type I and strain MRV3/TS/2012 was of type III. A sequence comparison showed that the isolates were 25.4% identical in the S1 gene.
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