Evidence map›Paper›PMID 32335736›Full record

ArticleEJNMMI research2020

Toxicity of a combined therapy using the mTOR-inhibitor everolimus and PRRT with [

Johannes Zellmer, Hsi-Yu Yen, Lena Kaiser, Erik Mille, Franz Josef Gildehaus, Guido Böning, Katja Steiger, Marcus Hacker, Peter Bartenstein, Andrei Todica and 2 more

Open access · goldAbstract read
In one paragraph

Article in EJNMMI research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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  6. Combination Strategies to Improve Targeted Radionuclide Therapy.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Johannes ZellmerDepartment of Nuclear Medicine, University Hospital, Ludwig-Maxilimians-University Munich, Munich, Germany.
Hsi-Yu YenDepartment of Pathology, Technical University of Munich, Munich, Germany.
Lena KaiserDepartment of Nuclear Medicine, University Hospital, Ludwig-Maxilimians-University Munich, Munich, Germany.
Erik MilleDepartment of Nuclear Medicine, University Hospital, Ludwig-Maxilimians-University Munich, Munich, Germany.
Franz Josef GildehausDepartment of Nuclear Medicine, University Hospital, Ludwig-Maxilimians-University Munich, Munich, Germany.
Guido BöningDepartment of Nuclear Medicine, University Hospital, Ludwig-Maxilimians-University Munich, Munich, Germany.
Katja SteigerDepartment of Pathology, Technical University of Munich, Munich, Germany.
Marcus HackerDepartment of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria.
Peter BartensteinDepartment of Nuclear Medicine, University Hospital, Ludwig-Maxilimians-University Munich, Munich, Germany.
Andrei TodicaDepartment of Nuclear Medicine, University Hospital, Ludwig-Maxilimians-University Munich, Munich, Germany.
Alexander R HaugDepartment of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria.
Harun IlhanDepartment of Nuclear Medicine, University Hospital, Ludwig-Maxilimians-University Munich, Munich, Germany. harun.ilhan@med.uni-muenchen.de.
Ludwig-Maximilians-Universität München · DEMedical University of Vienna · ATHeidelberg University · DETechnical University of Munich · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePeptide receptor radionuclide therapy (PRRT) with [

methodsAnimals received 200 MBq of [

resultsRats receiving everolimus showed a significantly lower increase in creatinine levels than those receiving placebo. Everolimus therapy reduced white blood count significantly, which was not observed for [

conclusionRenal scintigraphy is a highly sensitive tool for the detection of renal function impairment after a combination of everolimus and PRRT. Additional treatment with everolimus does not increase renal and haematological toxicity of PRRT with [

Indexed as

[177Lu]Lu-DOTA-TATEEverolimusPRRTRenal clearanceScintigraphy

Identifiers

PMID32335736
PMCPMC7183514
OpenAlexW3018299836

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.