ArticleAnalytical and bioanalytical chemistry2020
Examining NTA performance and potential using fortified and reference house dust as part of EPA's Non-Targeted Analysis Collaborative Trial (ENTACT).
Article in Analytical and bioanalytical chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Standard Reference Material (SRM®) 1950 metabolites in frozen human plasma-use, impact, lessons learned, and future perspectives.Analytical and bioanalytical chemistry · 2026Review
- The PFAS roadmap-Navigating a path together to improved management.Sustainability science and technology · 2026Article
- Eco-Friendly Sample Preparation Trends for Exogenous Toxic Organic Compounds in Food: A Sustainable Perspective for LC-MS Analysis.Foods (Basel, Switzerland) · 2026Review
- The impact of particle size on PFAS concentrations in dust from homes in North Carolina and New York and implications for exposure.Aerosol science and technology : the journal of the American Association for Aerosol Research · 2026Article
- Applying Nontargeted Analysis to Explore the Chemical Composition of Dust Collected in Infants' Homes.Environmental science & technology · 2025Article
- Improving predictions of compound amenability for liquid chromatography-mass spectrometry to enhance non-targeted analysis.Analytical and bioanalytical chemistry · 2024Article
- Establishing performance metrics for quantitative non-targeted analysis: a demonstration using per- and polyfluoroalkyl substances.Analytical and bioanalytical chemistry · 2024Article
- Burning questions: Current practices and critical gaps in evaluating removal of per- and polyfluoroalkyl substances (PFAS) during pyrolysis treatments of biosolids.Journal of hazardous materials letters · 2023Article
- Critical Assessment of the Chemical Space Covered by LC-HRMS Non-Targeted Analysis.Environmental science & technology · 2023Review
- Non-targeted analysis (NTA) and suspect screening analysis (SSA): a review of examining the chemical exposome.Journal of exposure science & environmental epidemiology · 2023Review
- Practical application guide for the discovery of novel PFAS in environmental samples using high resolution mass spectrometry.Journal of exposure science & environmental epidemiology · 2023Article
- Demonstrating the Use of Non-targeted Analysis for Identification of Unknown Chemicals in Rapid Response Scenarios.Environmental science & technology · 2023Article
- Evaluation of a rapid, generic human gestational dose model.Reproductive toxicology (Elmsford, N.Y.) · 2022Article
- Approaches for assessing performance of high-resolution mass spectrometry-based non-targeted analysis methods.Analytical and bioanalytical chemistry · 2022Article
- Uncertainty estimation strategies for quantitative non-targeted analysis.Analytical and bioanalytical chemistry · 2022Article
- An Introduction to the Benchmarking and Publications for Non-Targeted Analysis Working Group.Analytical chemistry · 2021Article
- Predicting compound amenability with liquid chromatography-mass spectrometry to improve non-targeted analysis.Analytical and bioanalytical chemistry · 2021Article
- Prevalence and Implications of Per- and Polyfluoroalkyl Substances (PFAS) in Settled Dust.Current environmental health reports · 2021Review
- patRoon: open source software platform for environmental mass spectrometry based non-target screening.Journal of cheminformatics · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Non-targeted analysis (NTA) methods are being increasingly used to aid in the identification of unknown compounds in the environment, a problem that has challenged environmental chemists for decades. Despite its increased use, quality assurance practices for NTA have not been well established. Furthermore, capabilities and limitations of certain NTA methods have not been thoroughly evaluated. Standard reference material dust (SRM 2585) was used here to evaluate the ability of NTA to identify previously reported compounds, as well as a suite of 365 chemicals that were spiked at various stages of the analytical procedure. Analysis of the unaltered SRM 2585 extracts revealed that several previously reported compounds can be identified by NTA, and that correct identification was dependent on concentration. A manual inspection of unknown features in SRM 2585 revealed the presence of two chlorinated and fluorinated compounds in high abundance, likely precursors to perfluorooctane sulfonate (PFOS) and perfluorohexane sulfonate (PFHxS). A retrospective analysis of data from the American Healthy Homes Survey revealed that these compounds were present in 42% of sampled homes. Spiking the dust at various stages of sample preparation revealed losses from extraction, cleanup, and instrumental analysis; the log K
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.