ArticleEpilepsy research2020
Juvenile myoclonic epilepsy shows increased posterior theta, and reduced sensorimotor beta resting connectivity.
Article in Epilepsy research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Transcriptional and neurotransmitter signatures associated with regional gray matter alterations in juvenile myoclonic epilepsy.Frontiers in molecular neuroscience · 2026Article
- Quantitative EEG signatures in patients with and without epilepsy development after a first seizure.Epilepsia open · 2025Article
- Altered effective connectivity of the default mode network in juvenile myoclonic epilepsy.Cognitive neurodynamics · 2024Article
- Article
- Comparison of Resting-State EEG Network Analyses With and Without Parallel MRI in Genetic Generalized Epilepsy.Brain topography · 2023Article
- The role of additive and diffusive coupling on the dynamics of neural populations.Scientific reports · 2023Article
- MEG Node Degree for Focus Localization: Comparison with Invasive EEG.Biomedicines · 2023Article
- Phase Lag Analysis Scalp Electroencephalography May Predict Seizure Frequencies in Patients with Childhood Epilepsy with Centrotemporal Spikes.Yonago acta medica · 2023Article
- Electroencephalogram in low-risk term newborns predicts neurodevelopmental metrics at age two years.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2022Article
- Article
- Genetic generalized epilepsies in adults - challenging assumptions and dogmas.Nature reviews. Neurology · 2022Review
- Contributions of Magnetoencephalography to Understanding Mechanisms of Generalized Epilepsies: Blurring the Boundary Between Focal and Generalized Epilepsies?Frontiers in neurology · 2022Review
- Alterations of the intrinsic amygdala-hippocampal network in juvenile myoclonic epilepsy.Brain and behavior · 2021Article
- A computational biomarker of juvenile myoclonic epilepsy from resting-state MEG.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021Article
- Presurgical Evaluation of Epilepsy Using Resting-State MEG Functional Connectivity.Frontiers in human neuroscience · 2021Review
- Altered dynamic effective connectivity of the default mode network in newly diagnosed drug-naïve juvenile myoclonic epilepsy.NeuroImage. Clinical · 2020Article
- Safety and Efficacy of Clonazepam in the Treatment of Juvenile Myoclonic Epilepsy: A Meta-Analysis.Journal of pharmacy & bioallied sciencesArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundWidespread structural and functional brain network changes have been shown in Juvenile Myoclonic Epilepsy (JME) despite normal clinical neuroimaging. We sought to better define these changes using magnetoencephalography (MEG) and source space connectivity analysis for optimal neurophysiological and anatomical localisation.
methodsWe consecutively recruited 26 patients with JME who underwent resting state MEG recording, along with 26 age-and-sex matched controls. Whole brain connectivity was determined through correlation of Automated Anatomical Labelling (AAL) atlas source space MEG timeseries in conventional frequency bands of interest delta (1-4 Hz), theta (4-8 Hz), alpha (8-13 Hz), beta (13-30 Hz) and gamma (40-60 Hz). We used a Linearly Constrained Minimum Variance (LCMV) beamformer to extract voxel wise time series of 'virtual sensors' for the desired frequency bands, followed by connectivity analysis using correlation between frequency- and node-specific power fluctuations, for the voxel maxima in each AAL atlas label, correcting for noise, potentially spurious connections and multiple comparisons.
resultsWe found increased connectivity in the theta band in posterior brain regions, surviving statistical correction for multiple comparisons (corrected p < 0.05), and decreased connectivity in the beta band in sensorimotor cortex, between right pre- and post- central gyrus (p < 0.05) in JME compared to controls.
conclusionsAltered resting-state MEG connectivity in JME comprised increased connectivity in posterior theta - the frequency band associated with long range connections affecting attention and arousal - and decreased beta-band sensorimotor connectivity. These findings likely relate to altered regulation of the sensorimotor network and seizure prone states in JME.
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