Evidence map›Paper›PMID 32335171›Full record

ArticleThe Journal of infection2020

Clinical and epidemiological features of COVID-19 family clusters in Beijing, China.

Rui Song, Bing Han, Meihua Song, Lin Wang, Christopher P Conlon, Tao Dong, Di Tian, Wei Zhang, Zhihai Chen, Fujie Zhang and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infection, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 13 pooled it
2.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 13 syntheses or guidelines pooled it, 97 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. The role of asymptomatic and pre-symptomatic infection in SARS-CoV-2 transmission-a living systematic review.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2021
    Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Rui SongThe Infectious Disease Diagnostic, Therapeutic and Research Centers, Beijing Ditan Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory of Emerging and Re-emerging Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Bing HanThe Infectious Disease Diagnostic, Therapeutic and Research Centers, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Meihua SongThe Infectious Disease Diagnostic, Therapeutic and Research Centers, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Lin WangThe Infectious Disease Diagnostic, Therapeutic and Research Centers, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Christopher P ConlonInfectious Diseases, Nuffield Department of Medicine, University of Oxford, Oxford, UK; Chinese Academy of Medical Sciences Oxford Institute, Nuffield Department of Medicine, Oxford University, Oxford, UK.
Tao DongChinese Academy of Medical Sciences Oxford Institute, Nuffield Department of Medicine, Oxford University, Oxford, UK; MRC Human Immunology Unit, MRC weatherall Institute of Molecular Medicine, Oxford University, Oxford, UK.
Di TianThe Infectious Disease Diagnostic, Therapeutic and Research Centers, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Wei ZhangThe Infectious Disease Diagnostic, Therapeutic and Research Centers, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Zhihai ChenThe Infectious Disease Diagnostic, Therapeutic and Research Centers, Beijing Ditan Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory of Emerging and Re-emerging Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Fujie ZhangThe Infectious Disease Diagnostic, Therapeutic and Research Centers, Beijing Ditan Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory of Emerging and Re-emerging Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Mang ShiSchool of Medicine, Sun Yat-sen University, Guangzhou, China. Electronic address: shim23@mail.sysu.edu.cn.
Xingwang LiThe Infectious Disease Diagnostic, Therapeutic and Research Centers, Beijing Ditan Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory of Emerging and Re-emerging Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China. Electronic address: ditanlxw@163.com.
Capital Medical University · CNBeijing Ditan Hospital · CNAcademy of Medical Sciences · GBChinese Academy of Medical Sciences & Peking Union Medical College · CNSun Yat-sen University · CN

Funding

Medical Research Council MR/L018942/1
6 · The paper itself

Abstract

backgroundSince its discovery, SARS-CoV-2 has been spread throughout China before becoming a global pandemic. In Beijing, family clusters are the main mode of human-human transmission accounting for 57.6% of the total confirmed cases.

methodWe present the epidemiological and clinical features of the clusters of three large and one small families.

resultOur results revealed that SARS-CoV-2 is transmitted quickly through contact with index case, and a total of 22/24 infections were observed. Among those infected, 20/22 had mild symptoms and only two had moderate to severe clinical manifestations. Children in the families generally showed milder symptoms. The incubation period varied from 2 to 13 days, and the shedding of virus from the upper respiratory tract lasted from 5 to over 30 days. A prolonged period of virus shedding (>30 days) in upper respiratory tract was observed in 6/24 cases.

conclusionSARS-CoV-2 is transmitted quickly in the form of family clusters. While the infection rate is high within the cluster, the disease manifestations, latent period, and virus shedding period varied greatly. We therefore recommend rigorously testing contacts even during the no-symptom phase and consider whether viral shedding has ceased before stopping isolation measures for an individual.

Indexed as

FamilyAdultAgedAged, 80 and overBeijingBetacoronavirusChildChild, PreschoolCoronavirus InfectionsCOVID-19FemaleHumansInfantMaleMiddle AgedPandemicsCoronavirus disease-19COVID-19Epidemiological featuresFamily clustersSARS-CoV-2

Identifiers

PMID32335171
PMCPMC7177072
OpenAlexW3019982998

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.