Evidence map›Paper›PMID 32335077›Full record

ArticleJournal of neuroscience methods2020

High-resolution MEMRI characterizes laminar specific ascending and descending spinal cord pathways in rats.

Vijai Krishnan, Jiadi Xu, Albert German Mendoza, Alan Koretsky, Stasia A Anderson, Galit Pelled

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroscience methods, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Frontiers in neuroscience · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Vijai KrishnanDepartment of Biomedical Engineering, Michigan State University, East Lansing, MI, United States; The Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, United States.
Jiadi XuJohns Hopkins Medicine Department of Radiology and Radiological Science, Baltimore, MD, United States.
Albert German MendozaJohns Hopkins Medicine Department of Radiology and Radiological Science, Baltimore, MD, United States.
Alan KoretskyLaboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States.
Stasia A AndersonNational Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Galit PelledDepartment of Biomedical Engineering, Michigan State University, East Lansing, MI, United States; The Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, United States; Department of Radiology, Michigan State University, East Lansing, MI, United States; Johns Hopkins Medicine Department of Radiology and Radiological Science, Baltimore, MD, United States. Electronic address: pelledga@msu.edu.
Johns Hopkins University · USNational Institutes of Health · USMichigan State University · US

Funding

MRI contrast for molecular and cellular imaging of the brainZIANS003047 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI KORETSKY, ALAN · 2009 to 2025
$29.3M
The Role of the Transcallosal Pathway in Neuroplasticity Following Nerve InjuryR01NS072171 · NINDS · MICHIGAN STATE UNIVERSITY · PI PELLED, GALIT · 2010 to 2019
$3.5M
Bioengineering a novel electromagnetic perspective gene as a tool for wireless control of excitable cellsR01NS098231 · NINDS · MICHIGAN STATE UNIVERSITY · PI GILAD, ASSAF A, PELLED, GALIT · 2017 to 2021
$2.6M
NINDS NIH HHS R01 NS072171NINDS NIH HHS R01 NS098231
6 · The paper itself

Abstract

backgroundThe spinal cord is composed of nine distinct cellular laminae that currently can only be visualized by histological methods. Developing imaging methods that can visualize laminar architecture in-vivo is of significant interest. Manganese enhanced magnetic resonance imaging (MEMRI) yields valuable architectural and functional information about the brain and has great potential in characterizing neural pathways in the spinal cord. Here we apply MEMRI to visualize laminae architecture in the thoracic region of the spinal cord with ultra-high resolution. NEW

methodManganese chloride (MnCl

resultsHere we demonstrate laminar specific signal enhancement in the spinal cord of rats administered with MnCl COMPARISONS WITH EXISTING

methodsThis is the first study to demonstrate that MEMRI is capable of identifying spinal laminae at a high resolution of 69 μm in a living animal. This would enable the visualization of architecture and function of distinct regions with improved resolution, in healthy and diseased animal models.

conclusionsThe regions with the largest T1 enhancements were observed to correspond to laminae that contain either high cell density or large motor neurons, making MEMRI an excellent tool for studying spinal cord architecture, physiology and function in different animal models.

Indexed as

Image EnhancementMagnetic Resonance ImagingAnimalsBrainManganeseRatsSpinal CordManganeseManganese enhanced magnetic resonance imagingMotor neuronsNon-InvasiveSpinal cord

Identifiers

PMID32335077
PMCPMC7281828
OpenAlexW3017655074

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.