ArticleBMC pulmonary medicine2020
People-centred care versus clinic-based DOT for continuation phase TB treatment in Armenia: a cluster randomized trial.
Article in BMC pulmonary medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02082340 (Innovative Approach in Tuberculosis Care in Armenia), which is not on this map. Cited by 21 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Innovative Approach in Tuberculosis Care in Armenia
Who cites it
21 citing papers in PubMed, 5 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- The impact of digital adherence technologies on treatment outcomes, adherence, and patient-reported outcomes in tuberculosis: a systematic review and meta-analysis.BMC infectious diseases · 2025Pooled it
- Comparative Effectiveness of Digital Health Technologies in Tuberculosis Treatment: Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.JMIR mHealth and uHealth · 2025Pooled it
- A meta-analysis of technology-based interventions on treatment adherence and treatment success among TBC patients.PloS one · 2024Pooled it
- eHealth in TB clinical management.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2022Pooled it
- Pooled it
- Effects of the LEARNS model-based self-management education on short-term treatment outcomes among newly diagnosed tuberculosis patients: a randomized controlled trial.Frontiers in public health · 2026Trial
- Trial
- Nurses' Experiences of Video Direct Observed Treatment at a Local Tuberculosis Clinic in a High-Income Country: A Qualitative Study.Nursing open · 2026Article
- Methodologies for studying depression in persons with tuberculosis: A scoping review.PLOS global public health · 2026Article
- Knowledge, practices, and concerns of tuberculosis healthcare workers at primary settings in western China: a multi-center cross-sectional study.Infectious diseases of poverty · 2025Article
- Contextual factors influencing implementation of tuberculosis digital adherence technologies: a scoping review guided by the RE-AIM framework.BMJ global health · 2025Article
- Effectiveness of Digital Health Interventions to Enhance Continuity of Care in Patients with Pulmonary Tuberculosis: A Systematic Review of Randomized Controlled Trials.Patient preference and adherence · 2025Review
- Level of Family Support and Associated Factors Among Pulmonary Tuberculosis Patients in Eastern Uganda. A Baseline Cross-Sectional Study.Journal of multidisciplinary healthcare · 2025Article
- Digital Health Interventions to Enhance Tuberculosis Treatment Adherence: Scoping Review.JMIR mHealth and uHealth · 2023Article
- Psychosocial support interventions to improve treatment outcomes for people living with tuberculosis: a mixed methods systematic review and meta-analysis.EClinicalMedicine · 2023Article
- Improving Tuberculosis Medication Adherence: The Potential of Integrating Digital Technology and Health Belief Model.Tuberculosis and respiratory diseases · 2023Article
- A randomized controlled trial to evaluate the impact of pharmacist-led clinical interventions on the health-related quality of life among TB patients.Frontiers in pharmacology · 2023Article
- Exploring the tuberculosis medication program in Indonesia as perceived by patients and their families: A qualitative study.Belitung nursing journal · 2023Article
- Primary healthcare providers challenged during the COVID-19 pandemic: a qualitative study.BMC primary care · 2022Article
- Factors Influencing Treatment Adherence Among Drug-Sensitive Tuberculosis (DS-TB) Patients in Armenia: A Qualitative Study.Patient preference and adherence · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundWHO's directly observed therapy (DOT) strategy for tuberculosis (TB) treatment depends upon a well-organized healthcare system. This study sought to evaluate the effectiveness of self-administered drug intake supported by a family member versus in-clinic DOT.
methodsThis open-label, nationally-representative stratified cluster randomized controlled non-inferiority trial with two parallel equal arms involved drug-susceptible pulmonary TB patients in the continuation treatment phase. We randomly assigned outpatient-TB-centres (52 clusters) to intervention and control arms. The intervention included an educational/counseling session to enhance treatment adherence; weekly visits to outpatient-TB-centres to receive medication, and daily SMS medication reminders and phone calls to track adherence and record side effects. Controls followed clinical DOT at Outpatient-TB-centres. Both groups participated in baseline and 4-5 months follow-up surveys. The trial's non-inferiority comparisons include: treatment success as the clinical (primary) outcome and medication adherence (self-reported), knowledge, depressive symptoms, stigma, quality of life, and social support as non-clinical (secondary) outcomes.
resultsPer-protocol analysis showed that the intervention (n = 187) and control (n = 198) arms achieved successful treatment outcome of 92.0 and 92.9%, respectively, indicating that the treatment success in the intervention group was non-inferior to DOT. Knowledge, depression, stigma, quality of life, and social support also showed non-inferiority, demonstrating substantial improvement over time for knowledge (change in the intervention = 1.05: 95%CL (0.49, 1.60); change in the control = 1.09: 95%CL (0.56, 1.64)), depression score (change in the intervention = - 3.56: 95%CL (- 4.99, - 2.13); change in the control = - 1.88: 95% CL (- 3.26, - 0.49)) and quality of life (change in the intervention = 5.01: 95%CL (- 0.64, 10.66); change in the control = 7.29: 95%CL (1.77, 12.81)). The intervention resulted in improved treatment adherence.
conclusionsThis socially empowering alternative strategy might be a preferable alternative to DOT available to patients in Armenia and in other countries. Further research evaluating cost effectiveness of the intervention and generalizability of the results is warranted.
trial registrationClinicaltrials.gov: NCT02082340, March 10, 2014.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.