Evidence map›Paper›PMID 32334482›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2020

Correlation between HER2 Expression and Clinicopathological Features of Breast Cancer: A Cross- Sectional Study in Vietnam.

Thuan Dang Cong, Tung Nguyen Thanh, Quynh Anh Nguyen Phan, Ai Phuong Hoang Thi, Bao Song Nguyen Tran, Quoc Huy Nguyen Vu

Open access · goldAbstract read
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In one paragraph

Article in Asian Pacific journal of cancer prevention : APJCP, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Diagnostic Accuracy of Immunohistochemistry for HER2-Positive Breast Cancer.Asian Pacific journal of cancer prevention : APJCP · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Thuan Dang CongDepartment of Histology, Embryology, Pathology and Forensic, Hue University of Medicine and Pharmacy, Hue University, Vietnam.ORCID 0000-0002-2657-6791
Tung Nguyen ThanhDepartment of Histology, Embryology, Pathology and Forensic, Hue University of Medicine and Pharmacy, Hue University, Vietnam.ORCID 0000-0002-5215-383X
Quynh Anh Nguyen PhanDepartment of Histology, Embryology, Pathology and Forensic, Hue University of Medicine and Pharmacy, Hue University, Vietnam.
Ai Phuong Hoang ThiFaculty of Basic Science, Hue University of Medicine and Pharmacy, Hue University, Vietnam.
Bao Song Nguyen TranDepartment of Histology, Embryology, Pathology and Forensic, Hue University of Medicine and Pharmacy, Hue University, Vietnam.
Quoc Huy Nguyen VuDepartment of Obstetrics and Gynaecology, Hue University of Medicine and Pharmacy, Hue University, Vietnam.ORCID 0000-0002-4744-7059
Hue University · VN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHER2 is the target of the therapeutic agents which are used to treat HER2-positive breast cancer. Reports have shown that the HER2 oncogene expression and its association with clinicopathological factors remain unclear in breast cancer (BC) patients.  This study aimed to determine the correlation between HER2 expression and clinicalpathological characteristics of breast cancer in Vietnamese women.

methodsBetween June 2016 and August 2018, paraffin-embedded specimens from 237 patients with primary invasive breast carcinoma in Hue University Hospital and Hue Center Hospital, Hue city, Vietnam were examined for pathological features. The gene expression of HER2, ER, PR and Ki-67 were determined by immunohistochemistry (IHC). The gene amplification of Her2 was assessed by using Dual color in situ hybridization (DISH).

resultsThe most frequent histological type was invasive carcinoma of no special type (NST) with 77.35%, the highest percentage of patients with Grade II was detected (59.36%), tumor size > 2 cm accounted for 71.31% of cases, Lymph node metastases were available in 57.86% cases. Most patients were diagnosed at stage II (59.18%). The majority of patients were classified as moderate Nottingham prognostic index (54.9%). Estrogen receptor and Progesterone receptor were positive in 53.16% and 50.63%, respectively. 76.37% of cases were in high expression group of Ki-67 (≥14%). HER2 IHC 2+, 3+ were accounted for 28.69% and HER2 gene amplification was detected in 31% cases. HER2 gene amplification and/or overexpression was significantly associated with cell proliferation index Ki67. Furthermore, HER2 gene expression tended to be more frequently found in tumors with large tumor size, high grade, high stage and high Nottingham prognostic index and confirmed their prognostic independent role.

conclusionsOur data indicated that HER2 gene expression was significantly correlated with cell proliferation index Ki67, but not significantly associated with another clinicopathological factors in breast cancer of Vietnamese women.<br />.

Indexed as

Gene AmplificationAdultBiomarkers, TumorBreast NeoplasmsCross-Sectional StudiesErb-b2 Receptor Tyrosine KinasesFemaleFollow-Up StudiesHumansLymphatic MetastasisMiddle AgedNeoplasm InvasivenessPrognosisVietnamBiomarkers, TumorERBB2 protein, humanErb-b2 Receptor Tyrosine Kinasesbreast cancerclinicopathological featuresDISHHER2immunohistochemistry

Identifiers

PMID32334482
PMCPMC7445976
OpenAlexW3019742656

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.