Evidence map›Paper›PMID 32334466›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2020

XRCC1 Gene Polymorphism Increases the Risk of Hepatocellular Carcinoma in Egyptian Population.

Mary Naguib, Mohamed M Helwa, Mohammed M Soliman, Mohamed Abdel-Samiee, Ashraf M Eljaky, Osama Hammam, Hassan Zaghla, Eman Abdelsameea

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Asian Pacific journal of cancer prevention : APJCP, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Genotype and Association of XRCC1 Gene With Liver Disease in Chronic Hcv Patients.Asian Pacific journal of cancer prevention : APJCP · 2025
    Article
  3. Review
  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Mary NaguibDepartment of Clinical Pathology, National Liver Institute, Menoufia University, Egypt.
Mohamed M HelwaClinical Pathology Department, Faculty of Medicine, Menoufia University, Egypt.
Mohammed M SolimanClinical Pathology Department, Faculty of Medicine, Menoufia University, Egypt.
Mohamed Abdel-SamieeHepatology and Gastroenterology, National Liver Institute, Menoufia University, Menoufia, Egypt.ORCID 0000 0002 8970 0286
Ashraf M EljakyHepatology and Gastroenterology, National Liver Institute, Menoufia University, Menoufia, Egypt.
Osama HammamDepartment of Clinical Pathology, National Liver Institute, Menoufia University, Egypt.
Hassan ZaghlaHepatology and Gastroenterology, National Liver Institute, Menoufia University, Menoufia, Egypt.
Eman AbdelsameeaHepatology and Gastroenterology, National Liver Institute, Menoufia University, Menoufia, Egypt.ORCID 0000-0002-3225-7164
Menoufia University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several major risk factors for hepatocellular carcinoma (HCC) have been identified, including chronic infection of hepatitis B virus (HBV) and hepatitis C virus (HCV). Nevertheless, only a fraction of infected patients develops HCC during their lifetime suggesting that genetic factors might modulate HCC development. X-ray repair cross complementing group1 (XRCC1) participates in the repair pathways of DNA.

aimto investigate the association between XRCC1 gene polymorphism and HCC in Egyptian chronic hepatitis C patients.

methodsThis study was assessed on 40 patients with HCC secondary to chronic HCV infection who were compared to 20 cirrhotic HCV patients and 40- age and gender- matched healthy control group. After collection of relevant clinical data and basic laboratory tests, c.1517G>C SNP of XRCC1 gene polymorphism was performed by (PCR-RFLP) technique.

resultsA statistically higher frequency of XRCC1 (CC, GC) genotypes and increased (C) allele frequency in patients with HCC was found in comparison to cirrhotic HCV patients as well as control group. In addition, patients with the XRCC1 (CC, GC) genotypes had significantly higher number and larger size of tumor foci and significantly higher Child Pugh grades. Multivariate analysis showed that the presence of c.1517G>C SNP of XRCC1 gene is an independent risk for the development of HCC in chronic HCV patients with 3.7 fold increased risk of HCC development. IN

conclusionXRCC1 gene polymorphism could be associated with increased risk of HCC development in chronic HCV Egyptian patients.<br />.

Indexed as

Polymorphism, Single NucleotideAdultBiomarkers, TumorCarcinoma, HepatocellularCase-Control StudiesEgyptFemaleFollow-Up StudiesGenetic Association StudiesGenotypeHumansLiver NeoplasmsMaleMiddle AgedPrognosisX-ray Repair Cross Complementing Protein 1Biomarkers, TumorX-ray Repair Cross Complementing Protein 1XRCC1 protein, humanDNA RepairHepatocellular carcinomaRFLPSNPXRCC1

Identifiers

PMID32334466
PMCPMC7445958
OpenAlexW3018908343

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.