Evidence map›Paper›PMID 32333941›Full record

ReviewVirus research2020

Swine hepatitis E virus: Cross-species infection, pork safety and chronic infection.

Harini Sooryanarain, Xiang-Jin Meng

Open access · greenAbstract readReview
In one paragraph

Review in Virus research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. An Update in Knowledge of Pigs as the Source of Zoonotic Pathogens.Animals : an open access journal from MDPI · 2023
    Review
  15. Article
  16. Article
  17. [Advances in hepatitis E epidemiology].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2023
    Article
  18. Review
  19. Review
  20. Transmission of Hepatitis E Virus.Advances in experimental medicine and biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Harini SooryanarainDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
Xiang-Jin MengDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA. Electronic address: xjmeng@vt.edu.
Virginia–Maryland College of Veterinary Medicine · USVirginia Tech · US

Funding

A Chicken Model to Study Hepatitis E Virus PathogenesisR01AI050611 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI MENG, XIANG-JIN · 2002 to 2023
$6.1M
Mechanism of Hepatitis E Virus Replication and PathogenesisR01AI074667 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI MENG, XIANG-JIN · 2008 to 2016
$3.1M
Understanding the mechanism of neurological sequelae associated with hepatitis E virus infectionR21AI141677 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI MENG, XIANG-JIN · 2019 to 2020
$425k
NIAID NIH HHS R01 AI050611NIAID NIH HHS R01 AI074667NIAID NIH HHS R21 AI141677
6 · The paper itself

Abstract

Swine hepatitis E virus (swine HEV) belongs to the species Orthohepevirus A within the genus Orthohepevirus in the family Hepeviridae. Four different genotypes of swine HEV within the species Orthohepevirus A have been identified so far from domesticated and wild swine population: genotypes 3 (HEV-3) and 4 (HEV-4) swine HEVs are zoonotic and infect humans, whereas HEV-5 and HEV-6 are only identified from swine. As a zoonotic agent, swine HEV is an emerging public health concern in many industrialized countries. Pigs are natural reservoir for HEV, consumption of raw or undercooked pork is an important route of foodborne HEV transmission. Occupational risks such as direct contact with infected pigs also increase the risk of HEV transmission in humans. Cross-species infection of HEV-3 and HEV-4 have been documented under experimental and natural conditions. Both swine HEV-3 and swine HEV-4 infect non-human primates, the surrogates of man. Swine HEV, predominantly HEV-3, can establish chronic infection in immunocompromised patients especially in solid organ transplant recipients. The zoonotic HEV-3, and to lesser extent HEV-4, have also been shown to cause neurological diseases and kidney injury. In this review, we focus on the epidemiology of swine HEV, host and viral determinants influencing cross-species HEV infection, zoonotic infection and its associated pork safety concern, as well as swine HEV-associated chronic infection and neurological diseases.

Indexed as

AnimalsFood SafetyGenotypeHepatitis, ChronicHepatitis EHepatitis E virusHumansPhylogenyPork MeatSwineSwine DiseasesZoonosesChronic infectionCross-species infectionFoodborne infectionNeurological diseasesPork safetySwine hepatitis E virus (swine HEV)Zoonosis

Identifiers

PMID32333941
PMCPMC7249539
OpenAlexW3017550283

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.