Evidence map›Paper›PMID 32333709›Full record

ArticleCancer science2020

Rae1 drives NKG2D binding-dependent tumor development in mice by activating mTOR and STAT3 pathways in tumor cells.

Peiyan Zhao, Lei Yang, Xin Li, Wenting Lu, Fangjie Lu, Shengnan Wang, Ying Wang, Li Hua, Cuiyun Cui, Boqi Dong and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Peiyan ZhaoDepartment of Molecular Biology, College of Basic Medical Sciences and Institute of Pediatrics, The First Hospital of Jilin University, Jilin University, Changchun, China.
Lei YangDepartment of Molecular Biology, College of Basic Medical Sciences and Institute of Pediatrics, The First Hospital of Jilin University, Jilin University, Changchun, China.
Xin LiDepartment of Molecular Biology, College of Basic Medical Sciences and Institute of Pediatrics, The First Hospital of Jilin University, Jilin University, Changchun, China.
Wenting LuDepartment of Molecular Biology, College of Basic Medical Sciences and Institute of Pediatrics, The First Hospital of Jilin University, Jilin University, Changchun, China.
Fangjie LuDepartment of Molecular Biology, College of Basic Medical Sciences and Institute of Pediatrics, The First Hospital of Jilin University, Jilin University, Changchun, China.
Shengnan WangDepartment of Molecular Biology, College of Basic Medical Sciences and Institute of Pediatrics, The First Hospital of Jilin University, Jilin University, Changchun, China.
Ying WangDepartment of Molecular Biology, College of Basic Medical Sciences and Institute of Pediatrics, The First Hospital of Jilin University, Jilin University, Changchun, China.
Li HuaDepartment of Immunology, College of Basic Medical Sciences, Jilin University, Changchun, China.
Cuiyun CuiDepartment of Immunology, College of Basic Medical Sciences, Jilin University, Changchun, China.
Boqi DongDepartment of Immunology, College of Basic Medical Sciences, Jilin University, Changchun, China.
Yongli YuDepartment of Immunology, College of Basic Medical Sciences, Jilin University, Changchun, China.
Liying WangDepartment of Molecular Biology, College of Basic Medical Sciences and Institute of Pediatrics, The First Hospital of Jilin University, Jilin University, Changchun, China.ORCID https://orcid.org/0000-0002-9180-5829
Jilin University · CN

Funding

Natural Science Foundation of Jilin Province 20180101182JC
6 · The paper itself

Abstract

Natural killer group 2 member D (NKG2D) ligands (NKG2DLs) on tumor cells engage NKG2D and mediate killing by NKG2D

Indexed as

Signal TransductionAnimalsCell Line, TumorCell MovementCell ProliferationCytotoxicity Tests, ImmunologicDisease SusceptibilityFemaleGene ExpressionImmunohistochemistryKiller Cells, NaturalMiceNeoplasmsNK Cell Lectin-Like Receptor Subfamily KNuclear Matrix-Associated ProteinsNucleocytoplasmic Transport ProteinsKlrk1 protein, mouseNK Cell Lectin-Like Receptor Subfamily KNuclear Matrix-Associated ProteinsNucleocytoplasmic Transport ProteinsRae1 protein, mouseSTAT3 Transcription FactorTOR Serine-Threonine KinasesmTORnatural killer group 2 member D ligandsretinoic acid early inducible gene 1signal transducer and activator of transcription 3tumor development

Identifiers

PMID32333709
PMCPMC7385386
OpenAlexW3019281284

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.