ReviewHead & neck2020
Topical preparations to reduce SARS-CoV-2 aerosolization in head and neck mucosal surgery.
Review in Head & neck, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 5 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Effectiveness of mouthwashes on reducing SARS-CoV-2 viral load in oral cavity: a systematic review and meta-analysis.BMC oral health · 2023Pooled it
- Antimicrobial mouthwashes (gargling) and nasal sprays administered to patients with suspected or confirmed COVID-19 infection to improve patient outcomes and to protect healthcare workers treating them.The Cochrane database of systematic reviews · 2020Pooled it
- Use of antimicrobial mouthwashes (gargling) and nasal sprays by healthcare workers to protect them when treating patients with suspected or confirmed COVID-19 infection.The Cochrane database of systematic reviews · 2020Pooled it
- Antimicrobial mouthwashes (gargling) and nasal sprays to protect healthcare workers when undertaking aerosol-generating procedures (AGPs) on patients without suspected or confirmed COVID-19 infection.The Cochrane database of systematic reviews · 2020Pooled it
- COVID-19 pandemic and lacrimal practice: Multipronged resumption strategies and getting back on our feet.Indian journal of ophthalmology · 2020Guideline
- Pharmacokinetic-based failure of a detergent virucidal for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) nasal infections: A preclinical study and randomized controlled trial.International forum of allergy & rhinology · 2022Trial
- Article
- Repurposing povidone-iodine to reduce the risk of SARS-CoV-2 infection and transmission: a narrative review.Annals of medicine · 2022Review
- Article
- Diagnostic and surgical innovations in otolaryngology for adult and paediatric patients during the COVID-19 era.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2022Review
- Changes in reverse transcription polymerase chain reaction cycle threshold values of SARS-CoV-2 with topical povidone iodine use: A single-arm open-label interventional study.Journal of family medicine and primary care · 2022Article
- Impacts of the COVID-19 pandemic on elective cataract surgeries.Einstein (Sao Paulo, Brazil) · 2022Article
- Can povidone iodine gargle/mouthrinse inactivate SARS-CoV-2 and decrease the risk of nosocomial and community transmission during the COVID-19 pandemic? An evidence-based update.The Japanese dental science review · 2021Review
- Dental Healthcare Amid the COVID-19 Pandemic.International journal of environmental research and public health · 2021Review
- Evidence based management guidelines in dentistry during the COVID-19 pandemic - a review of the literature.Medicine and pharmacy reports · 2021Review
- Protective Measures against COVID-19: Dental Practice and Infection Control.Healthcare (Basel, Switzerland) · 2021Review
- Pharmacokinetic-based failure of a detergent virucidal for SARS-COV-2 nasal infections.Research square · 2021Article
- RE: Khan MA et al: Perceptions of Occupational Risk and Changes in Clinical Practice of U.S. Vitreoretinal Surgery Fellows during the COVID-19 Pandemic (Ophthalmol Retina. 2020;4:1181-1187).Ophthalmology. Retina · 2021Article
- The impact of oral health status on COVID-19 severity, recovery period and C-reactive protein values.British dental journal · 2021Article
- Innovations in otorhinolaryngology in the age of COVID-19: a systematic literature review.World journal of otorhinolaryngology - head and neck surgery · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has put health care workers at risk when exposed to aerosolized viral particles during upper airway mucosal surgery. The objective of this review was to discuss topical preparations that could be utilized preoperatively to help to decrease viral load and potentially reduce the risks of viral transmission.
methodsA PubMed/MEDLINE database review of articles was performed querying topical preparations with virucidal activity against coronaviruses.
resultsPovidone-iodine (PVP-I) solutions ranging from 0.23% to 7% have been found to demonstrate highly effective virucidal activity against a broad range of viruses including several coronaviruses responsible for recent epidemics including SARS-CoV-1 and MERS-CoV.
conclusionsWhile specific evidence regarding SARS-CoV-2 is lacking, PVP-I-based preparations have been successfully demonstrated to reduce viral loads of coronaviruses. They are relatively safe to use in the upper airway and may reduce risk of SARS-CoV-2 aerosolization during upper airway mucosal surgery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.