ArticleJournal of Alzheimer's disease : JAD2020
Sex-Specific Association of Lifetime Body Mass Index with Alzheimer's Disease Neuroimaging Biomarkers.
Article in Journal of Alzheimer's disease : JAD, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 10 citations in OpenAlex.
- Mapping sex-specific associations of adiposity with age-related cognitive decline and multimodal Alzheimer's pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Abdominal adiposity and Alzheimer's disease imaging markers across sex and race at midlife.Journal of Alzheimer's disease : JAD · 2026Article
- Associations of circulating resistin with Alzheimer's disease biomarkers and cognitive function in the preclinical stage of Alzheimer's disease.Journal of Alzheimer's disease : JAD · 2026Article
- Correlation Between the Dementia Assessment Sheet for Community-Based Integrated Care System-21 Scores and Criteria for Determination of the Daily Life Independence Level of Older Adults With Dementia Using the Diagnosis Procedure Combination Database.Geriatrics & gerontology international · 2026Article
- BMI changes from midlife to late life and their relationship with Alzheimer's disease pathologies.Alzheimer's research & therapy · 2026Observational
- Cardiovascular contributions to dementia: Examining sex differences and female-specific factors.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Plasma Leptin and Alzheimer Protein Pathologies Among Older Adults.JAMA network open · 2024Article
- Body mass index and two-year change of in vivo Alzheimer's disease pathologies in cognitively normal older adults.Alzheimer's research & therapy · 2023Article
- Associations among Body Mass Index, Waist-to-Hip Ratio, and Cognitive Impairment Tend to Follow an Opposite Trend and Are Sex Specific: A Population-Based Cross-Sectional Study in a Rural Area of Xi'an, China.Neuroepidemiology · 2023Article
- Cognitive Decline Related to Diet Pattern and Nutritional Adequacy in Alzheimer's Disease Using Surface-Based Morphometry.Nutrients · 2022Article
- Independent effect of body mass index variation on amyloid-β positivity.Frontiers in aging neuroscience · 2022Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough recent studies indicate that the relationship between body mass index (BMI) and Alzheimer's disease (AD) may differ by both sex and age of BMI measurement, little information is available on sex- or age-specific associations between BMI and AD neuropathologies.
objectiveTo examined whether sex-specific BMIs measured at different life-stages (in early adulthood, midlife, and late life) were associated with cerebral amyloid-β (Aβ) deposition and AD-signature region cortical thickness (AD-CT) in cognitively normal (CN) older adults.
methodsA total of 212 CN subjects aged 60-90 years (females 108, males 104), who participated in the Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer's Disease (KBASE), an ongoing prospective cohort study, were included. All participants underwent comprehensive clinical and neuropsychological assessments, [11C] Pittsburgh Compound B positron emission tomography, and brain magnetic resonance imaging. BMIs at different life stages were calculated. Multiple regression analyses were performed separately for either sex.
resultsIn males, lower early adulthood or midlife BMI was associated with greater cerebral Aβ deposition, but late life BMI was not. Lower midlife BMI was associated with reduced AD-CT, but the BMI in early adulthood and late life was not. In females, no significant association was observed between any lifetime BMI and Aβ deposition or AD-CT.
conclusionOur results support a male-specific association between BMI prior to late life, and in vivo AD pathologies. Avoiding underweight status early in life may be important to prevent AD dementia in males, but not females.
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